{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:23:36Z","timestamp":1791869016206,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["23590829"],"award-info":[{"award-number":["23590829"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26461426"],"award-info":[{"award-number":["26461426"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>There is evidence that radiation exposure is a causative factor of myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>). However, little is known about whether radiation exposure is also a prognostic factor of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>. We investigated the impact of radiation exposure on the prognosis of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> in Nagasaki atomic bomb survivors using the International Prognostic Scoring System (<jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>) and the revised version (<jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\u2010R). Subjects were 140 patients with primary <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> diagnosed between 1985 and 2011 and evaluable for <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IPSS<\/jats:styled-content>\u2010R, and exposure distance. Of those, 31 were exposed at &lt;1.5 km, 35 at 1.5\u20132.99 km, and 74 at \u22653.0 km. By the end of March 2014, 47 patients (34%) progressed to overt leukemia and 106 (75.7%) died. By comparing with patients exposed at \u22653.0 km, those exposed at &lt;1.5 km had significantly higher frequencies of abnormal chromosome (<jats:italic>P<\/jats:italic> = 0.02), intermediate\/poor <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>, and intermediate\/poor\/very poor <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\u2010R cytogenetic category (<jats:italic>P<\/jats:italic> = 0.0001, and <jats:italic>P<\/jats:italic> &lt; 0.0001, respectively). As with de novo <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>, multivariate Cox regression analyses revealed that cytogenetic abnormalities, <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content> karyotype, and <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\u2010R cytogenetics were significantly associated with poor survival, and cumulative incidence of leukemic transformation in <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> among atomic bomb survivors, but exposure distance was not associated with any poor outcomes. These suggest that exposure to the greater dose of atomic bomb radiation is associated with developing poor cytogenetic abnormalities in <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>, which might consequently lead to overt leukemia among atomic bomb survivors.<\/jats:p>","DOI":"10.1111\/cas.13025","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T15:25:38Z","timestamp":1470237938000},"page":"1484-1491","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki"],"prefix":"10.1111","volume":"107","author":[{"given":"Masatoshi","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Hematology Atomic Bomb Disease and Hibakusya Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan"},{"name":"Department of Hematology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Frontier Life Science Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Scientific Data Registry Atomic Bomb Disease and Hibakusya Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Soda","sequence":"additional","affiliation":[{"name":"Nagasaki Prefectural Cancer Registry Nagasaki Japan"},{"name":"Department of Epidemiology Radiation Effects Research Foundation Nagasaki 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