{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:18Z","timestamp":1787013978945,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:00:00Z","timestamp":1474675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["26462540"],"award-info":[{"award-number":["26462540"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007655","name":"Aichi Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007877","name":"Fujita Health University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Monitoring the attribution of human papillomavirus (HPV) genotypes to cervical precancerous lesions is essential in assessing the efficacy of HPV vaccines. To resolve the lack of studies comparing the HPV genotyping procedures used to estimate HPV genotype attribution, we undertook a retrospective cross\u2010sectional study to determine the appropriate genotyping procedures for evaluating the potential efficacy of HPV vaccines. Three procedures, including two different genotyping methods, Clinichip HPV test (C\u2010Chip) and modified GP5+\/6+ PCR coupled to fluorescent bead sorter detection (MGP), using exfoliated cervical cells (C\u2010Chip and C\u2010MGP, respectively) or formalin\u2010fixed paraffin\u2010embedded tissues (F\u2010MGP), were compared. The overall agreement in detecting high\u2010risk HPV was 88.5\u201392.1% among the three procedures, and genotype\u2010specific agreement was 83.9\u2013100% for all pairwise comparisons. In cervical intraepithelial neoplasia grade 2\/3 specimens, HPV16\/18 attribution estimated with the hierarchical attribution method was consistent among the procedures: 52.3% (45\/86) for C\u2010Chip, 54.7% (47\/86) for C\u2010MGP, and 52.3% (45\/86) for F\u2010MGP (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.81). HPV16\/18\/31\/33\/45\/52\/58 hierarchical attribution was 88.4% (76\/86) with C\u2010Chip, 86.0% (74\/86) with C\u2010MGP, and 83.7% (72\/86) with F\u2010MGP (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.49). In cervical intraepithelial neoplasia grade 3 specimens, the corresponding hierarchical attribution was 96.4% (53\/55) with C\u2010Chip, 89.1% (49\/55) with C\u2010MGP, and 94.5% (52\/55) with F\u2010MGP (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.27). Although F\u2010MGP is theoretically a reliable method for determining HPV genotype attribution, it is acceptable to use C\u2010Chip or C\u2010MGP, coupled to the hierarchical attribution formula to correct the bias of multiple infections. These approaches using exfoliated cervical cells are practical for monitoring the efficacy of HPV vaccines.\n                  <\/jats:p>","DOI":"10.1111\/cas.13030","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T14:16:53Z","timestamp":1470665813000},"page":"1520-1526","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of methods using paraffin\u2010embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution"],"prefix":"10.1111","volume":"107","author":[{"given":"Yutaka","family":"Torii","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Fujita Health University Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Fujita Health University Toyoake Japan"},{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Kukimoto","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Center National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Medical Statistics School of Medicine Fujita Health University Toyoake 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