{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:58:59Z","timestamp":1773698339755,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26293078"],"award-info":[{"award-number":["26293078"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Follicular lymphoma (FL<\/jats:styled-content>) shows co\u2010expression of B\u2010cell lymphoma 2 (BCL<\/jats:styled-content>2) and CD<\/jats:styled-content>10, whereas downexpression of CD<\/jats:styled-content>10 is occasionally experienced in gastrointestinal (GI<\/jats:styled-content>) FL<\/jats:styled-content> with unknown significance. Gastrointestinal FL<\/jats:styled-content> is a rare variant of FL<\/jats:styled-content>, and its similarity with mucosa\u2010associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD<\/jats:styled-content>10 downexpressed (CD<\/jats:styled-content>10down<\/jats:sup>) GI<\/jats:styled-content>\u2010FL<\/jats:styled-content>. The diagnosis of CD<\/jats:styled-content>10down<\/jats:sup> FL<\/jats:styled-content> was carried out with a combination of pathological and molecular analyses. The incidence of CD<\/jats:styled-content>10down<\/jats:sup> GI<\/jats:styled-content>\u2010FL<\/jats:styled-content> was shown in 35\/172 (20.3%) cases, which was more frequent than nodal FL<\/jats:styled-content> (3.5%, P<\/jats:italic> < 0.001). The difference was additionally significant between GI<\/jats:styled-content>\u2010FL<\/jats:styled-content> and nodal FL<\/jats:styled-content> when the analysis was confined to primary GI<\/jats:styled-content>\u2010FL<\/jats:styled-content> (55.2% vs<\/jats:italic> 3.5%, P <<\/jats:italic> 0.001). Compared to CD<\/jats:styled-content>10+<\/jats:sup> GI<\/jats:styled-content>\u2010FL<\/jats:styled-content>, CD<\/jats:styled-content>10down<\/jats:sup> GI<\/jats:styled-content>\u2010FL<\/jats:styled-content> significantly involved the stomach or large intestine (P<\/jats:italic> = 0.015), and additionally showed the downexpression of BCL<\/jats:styled-content>6 (P<\/jats:italic> < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD<\/jats:styled-content>10down<\/jats:sup> group (P<\/jats:italic> = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5\/12 (40%) gastric FL<\/jats:styled-content> cases, which indicated caution in the differentiation of mucosa\u2010associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD<\/jats:styled-content>10down<\/jats:sup> GI<\/jats:styled-content>\u2010FL<\/jats:styled-content>, and an identical clone was found between CD<\/jats:styled-content>10down<\/jats:sup> follicles and CD<\/jats:styled-content>10+<\/jats:sup>BCL<\/jats:styled-content>2+<\/jats:sup> neoplastic follicles. In the diagnosis of cases with CD<\/jats:styled-content>10down<\/jats:sup> BCL<\/jats:styled-content>2+<\/jats:sup> follicles, careful examination with molecular studies should be carried out.<\/jats:p>","DOI":"10.1111\/cas.13031","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T13:42:46Z","timestamp":1470922966000},"page":"1687-1695","source":"Crossref","is-referenced-by-count":17,"title":["CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine"],"prefix":"10.1111","volume":"107","author":[{"given":"Nobuhiko","family":"Ohnishi","sequence":"first","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Miyata\u2010Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tari","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hiroshima Red Cross Hospital and Atomic\u2010Bomb Survivors Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Gion","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Noujima\u2010Harada","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keina","family":"Nagakita","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuma","family":"Omote","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takahata","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Shikoku Cancer Center Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Iwamuro","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okayama University Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood-2006-09-045989","article-title":"CD10\u2010MUM1 + follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features","volume":"109","author":"Karube K","year":"2007","journal-title":"Blood"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403738"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01980.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01108.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200005000-00007"},{"key":"e_1_2_6_9_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966223"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12197"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9193"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.127"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12392"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058869"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.871634"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60695-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690501300110"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02951.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1182\/blood.V95.3.802.003k19_802_806","article-title":"Mucosa\u2010associated lymphoid tissue lymphoma is a disseminated disease in one\u2010third of 158 patients analyzed","volume":"95","author":"Thieblemont C","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1279"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn760"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.01011.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0552"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880284"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1996.tb01392.x"},{"key":"e_1_2_6_29_1","first-page":"343","article-title":"The diagnostic characteristics of a group of patients with primary gastric lymphoma: macroscopic, histopathological and immunohistochemical aspects","volume":"53","author":"Rotaru I","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02519.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-009-0477-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg168"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.5858\/2002-126-0956-CEIPIL","article-title":"CD10 expression in primary intestinal large B\u2010cell lymphomas: its clinical significance","volume":"126","author":"Go JH","year":"2002","journal-title":"Arch Pathol Lab Med"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.13031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:01:20Z","timestamp":1696222880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.13031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cas.13031"],"URL":"https:\/\/doi.org\/10.1111\/cas.13031","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}