{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:39:52Z","timestamp":1787168392722,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572654"],"award-info":[{"award-number":["81572654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n With the development of functional genomics studies, a mass of long non\u2010coding\n RNA<\/jats:styled-content>\n s (Lnc\n RNA<\/jats:styled-content>\n ) were discovered from the human genome. Long non\u2010coding\n RNA<\/jats:styled-content>\n s serve as pivotal regulators of genes that are able to generate Lnc\n RNA<\/jats:styled-content>\n \u2013binding protein complexes to modulate a great number of genes. Recently, the Lnc\n RNA<\/jats:styled-content>\n urothelial carcinoma\u2010associated 1 (\n UCA<\/jats:styled-content>\n 1) has been revealed to be dysregulated, which plays a critical role in the development of a few cancers. However, the role of the biology and clinical significance of\n UCA<\/jats:styled-content>\n 1 in the tumorigenesis of oral squamous cell carcinoma (\n OSCC<\/jats:styled-content>\n ) remain unknown. We found that\n UCA<\/jats:styled-content>\n 1 expression levels were upregulated aberrantly in tongue squamous cell carcinoma tissues and associated with lymph node metastasis and\n TNM<\/jats:styled-content>\n stage. We explored the expression, function, and molecular mechanism of Lnc\n RNA UCA<\/jats:styled-content>\n 1 in\n OSCC<\/jats:styled-content>\n . In the present work, we revealed that\n UCA<\/jats:styled-content>\n 1 silencing suppressed proliferation and metastasis and induced apoptosis of\n OSCC<\/jats:styled-content>\n cell lines\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n , which might be related to the activation level of the\n WNT<\/jats:styled-content>\n \/\u03b2\u2010catenin signaling pathway. Our research results emphasize the pivotal role of\n UCA<\/jats:styled-content>\n 1 in the oncogenesis of\n OSCC<\/jats:styled-content>\n and reveal a novel Lnc\n RNA UCA<\/jats:styled-content>\n 1\u2013\u03b2\u2010catenin\u2013\n WNT<\/jats:styled-content>\n signaling pathway regulatory network that could contribute to our understanding in the pathogenesis of\n OSCC<\/jats:styled-content>\n and assist in the discovery of a viable Lnc\n RNA<\/jats:styled-content>\n \u2010directed diagnostic and therapeutic strategy for this fatal disease.\n <\/jats:p>","DOI":"10.1111\/cas.13058","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T09:28:22Z","timestamp":1472117302000},"page":"1581-1589","source":"Crossref","is-referenced-by-count":122,"title":["Long non\u2010coding\n RNA UCA<\/scp>\n 1 contributes to the progression of oral squamous cell carcinoma by regulating the\n WNT<\/scp>\n \/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1111","volume":"107","author":[{"given":"Yong\u2010Tao","family":"Yang","sequence":"first","affiliation":[{"name":"Graduate school Guangzhou Medical University Guangzhou China"},{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Yi","family":"Lai","sequence":"additional","affiliation":[{"name":"Shenzhen TCM Hospital Guangzhou University of Traditional Chinese Medicine Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Yue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Shenzhen Peking University\u2013The Hong Kong University of Science and Technology Medical Center Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial surgery Peking University Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"64","article-title":"Oral cancer: enduring characteristics and emerging trends","volume":"91","author":"Rose Bush MS","year":"2011","journal-title":"J Tenn Dent Assoc"},{"key":"e_1_2_7_3_1","first-page":"72","article-title":"A comprehensive review of oral cancer","volume":"49","author":"Casiglia J","year":"2001","journal-title":"Gen Dent"},{"key":"e_1_2_7_4_1","first-page":"697","article-title":"Neoadjuvant and adjuvant therapy in patients with oral squamous cell carcinoma. Long\u2010term survival in a prospective, non\u2010randomized study","volume":"46","author":"Brown James S","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.09.163"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-38"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100084"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20481"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0658-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i2.134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.145"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08975"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10398"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.541"},{"key":"e_1_2_7_16_1","first-page":"276","article-title":"Long non\u2010coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer","volume":"41","author":"Wang Y","year":"2012","journal-title":"Int J Oncol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.05.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000125"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.09.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0134"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12737"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0492"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.12.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64955-3"},{"key":"e_1_2_7_25_1","first-page":"422","article-title":"Beta\u2010Catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"Tetsu O","year":"1999","journal-title":"Nat Int Week J Sci"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.10.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.012"},{"key":"e_1_2_7_28_1","first-page":"12609","article-title":"Long non\u2010coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4\u2010KRT6\/13 signaling pathway","volume":"8","author":"Na XY","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6349(08)71453-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.5794\/jjoms.57.533"},{"key":"e_1_2_7_31_1","first-page":"103","article-title":"Winding through the WNT pathway during cellular development and demise","volume":"21","author":"Li F","year":"2006","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-294"},{"key":"e_1_2_7_33_1","first-page":"1596","article-title":"Bioinformatics analysis and identification of transcriptional regulation of human UCA1 gene","volume":"33","author":"Xue M","year":"2013","journal-title":"J South Med Univ"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3092"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-92"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq285"},{"key":"e_1_2_7_37_1","article-title":"CARL LncRNA inhibits anoxia\u2010induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR\u2010539\u2010dependent PHB2 downregulation","volume":"5","author":"Wang K","year":"2014","journal-title":"Nat Commun"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.028"}],"updated-by":[{"DOI":"10.1111\/cas.15680","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000}}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.13058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:01:56Z","timestamp":1696208516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.13058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cas.13058"],"URL":"https:\/\/doi.org\/10.1111\/cas.13058","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}