{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:39:53Z","timestamp":1775115593361,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sport, Science, and Technology of Japan","doi-asserted-by":"crossref","award":["25461580"],"award-info":[{"award-number":["25461580"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>The Ewing sarcoma breakpoint region 1 (<jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1<\/jats:italic>) gene is known to fuse with various partner genes to promote the development of the Ewing sarcoma family of tumors and other sarcomas. In contrast, the association of <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1<\/jats:italic> chimeric fusion genes with leukemia has rarely been reported. We identified a novel <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1<\/jats:italic>\u2010associated chimeric fusion gene in a patient with acute myeloid leukemia harboring 46, <jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content>, t (11; 22) (p13; q12) karyotype abnormality. The patient was refractory to intensified chemotherapy including hematopoietic stem cell transplantation. Total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> paired\u2010end sequencing identified a novel chimeric fusion gene as <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">ELF<\/jats:styled-content>5<\/jats:italic>, a member of the E26 transformation\u2010specific transcription factor family. Transduction of <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">ELF<\/jats:styled-content>5<\/jats:italic> to <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>3T3 cells induced transformation by attenuating with the p53\/p21\u2010dependent pathway. The injection of <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">ELF<\/jats:styled-content>5\u2010<\/jats:italic>transduced <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content>3T3 cells into <jats:styled-content style=\"fixed-case\">NSG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> mice systematically induced the development of tumors <jats:italic>in vivo<\/jats:italic>. These results revealed the oncogenic potency of <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">ELF<\/jats:styled-content>5<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cas.13080","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T16:42:39Z","timestamp":1473871359000},"page":"1745-1754","source":"Crossref","is-referenced-by-count":20,"title":["<i><scp>EWSR<\/scp>1\/<scp>ELF<\/scp>5<\/i> induces acute myeloid leukemia by inhibiting p53\/p21 pathway"],"prefix":"10.1111","volume":"107","author":[{"given":"Akifumi","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Developmental Biology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology Tokyo Medical and 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