{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:15:50Z","timestamp":1782602150528,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Patients with advanced esophageal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content>) is received chemoradiotherapy or chemotherapy for clinical management. However, it is difficult to predict tumor response and prognosis using blood markers before starting treatments. The purpose of this study was to investigate the pre\u2010treatment plasma fibrinogen and neutrophil\u2013lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) in patients with advanced <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content> treated with chemoradiotherapy or chemotherapy, and to assess the clinical utility of a combined score using these blood markers, named as the F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> (fibrinogen and <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) score, as a predictor of tumor response and prognosis. A total of 98 advanced <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content> patients, treated with chemoradiotherapy or chemotherapy, were classified into three groups: F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score of 2, having both hyperfibrinogenemia (&gt;400\u00a0mg\/dL) and high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> (&gt;3.0), score of 1, one of these hematological abnormalities, and score of 0, having neither hyperfibrinogenemia nor high <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>. Fibrinogen and <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> were significantly higher in the progressive disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) group than the non\u2010<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0419, and <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0001, respectively). A significantly higher F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score was found in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group than the non\u2010<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0140). Overall survival was significantly lower in patients with an F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score of 2 than in those with an F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score of 0 or 1 (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.0001). Multivariate analysis showed that the F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score was one of the independent prognostic factors (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0081). Our study demonstrates that the F\u2010<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> score is promising as a predictive marker for therapeutic effects and prognosis in patients with advanced <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.13127","type":"journal-article","created":{"date-parts":[[2016,11,27]],"date-time":"2016-11-27T08:52:43Z","timestamp":1480236763000},"page":"193-199","source":"Crossref","is-referenced-by-count":59,"title":["Combined fibrinogen and neutrophil\u2010lymphocyte ratio as a prognostic marker of advanced esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"108","author":[{"given":"Takashi","family":"Kijima","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery, Breast and Thyroid Surgery Field of Oncology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 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