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The function of taurine upregulated gene 1 (<jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1) and its mechanism in osteosarcoma remain unclear. In our research, we found that <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 was elevated and correlated with a poor prognosis in osteosarcoma patients. In addition, the following functional experiment showed that decreased <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 could remarkably inhibit osteosarcoma cell migration and invasion, indicating that <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 functioned as an oncogene in osteosarcoma. Moreover, we revealed that <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 and Rho\u2010associated coiled\u2010coil\u2010containing protein kinase 1 (<jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1), a metastasis\u2010related gene targeted by micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010335\u20105p (miR\u2010335\u20105p), had the same miR\u2010335\u20105p combining site. The subsequent luciferase assay verified <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 was a target of miR\u2010335\u20105p. Furthermore, the results of a real\u2010time quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> showed that <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 and miR\u2010335\u20105p could affect each other's expression. respectively. Finally, we affirmed that <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 affected <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1 expression and <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1\u2010mediated migration\/invasion by working as a competitive endogenous <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) via miR\u2010335\u20105p. In summary, the findings of this study, based on ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> theory, combining the research foundation of miR\u2010335\u20105p and <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1, and taking <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>1 as a new study point, provide new insight into molecular\u2010level reversing migration and invasion of osteosarcoma.<\/jats:p>","DOI":"10.1111\/cas.13201","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T04:57:17Z","timestamp":1487221037000},"page":"859-867","source":"Crossref","is-referenced-by-count":106,"title":["Long non\u2010coding <scp>RNA TUG<\/scp>1 promotes migration and invasion by acting as a ce<scp>RNA<\/scp> of miR\u2010335\u20105p in osteosarcoma cells"],"prefix":"10.1111","volume":"108","author":[{"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"The 4th Department of 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