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In addition, we found that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> can secrete different types of factors. However, the involvement of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010derived factors in human tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>) growth has not been clearly addressed. The <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content> family includes multifunctional signaling molecules that affect the initiation and development events of various tumors. In our study, we report that <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2\/connective tissue growth factor (<jats:styled-content style=\"fixed-case\">CTGF<\/jats:styled-content>) was the most highly induced among the <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content> family members in <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> that were co\u2010cultured with <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cells. To evaluate the relationship between <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> growth, we downregulated <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 expression with sh<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> targeting <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 and found that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010secreted <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 promotes <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cell proliferation, migration and invasion. We also confirmed that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 partially accelerated tumor growth <jats:italic>in vitro<\/jats:italic>. Taken together, these results suggest that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">CCN<\/jats:styled-content>2 contributes to the promotion of proliferation, migration and invasion of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cells and may be a possible therapy target in the future.<\/jats:p>","DOI":"10.1111\/cas.13202","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T22:23:04Z","timestamp":1487283784000},"page":"897-909","source":"Crossref","is-referenced-by-count":40,"title":["Mesenchymal stem cell\u2010derived <scp>CCN<\/scp>2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-7470","authenticated-orcid":false,"given":"Yu\u2010Ling","family":"Wu","sequence":"first","affiliation":[{"name":"Department 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