{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:28:26Z","timestamp":1790044106327,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup>) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0\/1 (<jats:italic>n\u00a0=\u00a0<\/jats:italic>911) or R2 (<jats:italic>n\u00a0=\u00a0<\/jats:italic>117) resections and analyzed relationships between cancer cell findings in peritoneal lavage fluid and clinicopathological factors in the R0\/1 group. We found 68 patients with <jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup> status. Receiver operating characteristic analyses and multivariate analyses showed that the presence of \u22651 signet ring cell, \u22655 cell clusters or \u226550 isolated cancer cells in peritoneal lavage fluid predicted poor prognoses in the 68 <jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup> patients. High\u2010risk <jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup> group patients with at least one of the above predictors had the highest hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a03.28, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). The remaining (low\u2010risk) patients had a survival curve similar to that of patients with a normal cytology. The high\u2010risk <jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup> patients who underwent R1 resection had poor prognoses despite no macroscopic peritoneal metastasis (2% 5\u2010year survival)\u2014equivalent to that of patients who underwent R2 resection. The <jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content><jats:sup>+<\/jats:sup> criteria defined in this study could help identify candidates for curative resection as an initial therapy for gastric cancer.<\/jats:p>","DOI":"10.1111\/cas.13219","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T06:36:39Z","timestamp":1488522999000},"page":"978-986","source":"Crossref","is-referenced-by-count":26,"title":["Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-7302","authenticated-orcid":false,"given":"Eiji","family":"Higaki","sequence":"first","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center Kashiwa Japan"},{"name":"Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine Kashiwa Japan"},{"name":"Department of Surgical Oncology National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Gotohda","sequence":"additional","affiliation":[{"name":"Division of Hepatobilliary and Pancreatic Surgery National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kuwata","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Pathology Exploratory Oncology Research &amp; Clinical Trial Center National Cancer Center Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,22]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin L","year":"2009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-9759-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00162-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199910)72:2<60::AID-JSO3>3.0.CO;2-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.03.065"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3406"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690096"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5196"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-7901-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603909"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0396-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9684"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200204000-00007"},{"key":"e_1_2_6_15_1","first-page":"5570","article-title":"Detection of peritoneal micrometastases of gastric carcinoma with green fluorescent protein and carcinoembryonic antigen promoter","volume":"61","author":"Kaneko K","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.03.022"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-007-0436-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b21c7b"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9351-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00086-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24188"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00078-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1720"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s595-002-8110-6"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:02:55Z","timestamp":1695513775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.13219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cas.13219"],"URL":"https:\/\/doi.org\/10.1111\/cas.13219","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}