{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:19:20Z","timestamp":1791944360934,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672468"],"award-info":[{"award-number":["81672468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Several studies have produced contradictory findings about the prognostic implications for inhibitor of apoptosis proteins (\n IAP<\/jats:styled-content>\n ) in different types of cancer. Cellular inhibitor of apoptosis 2 (\n cIAP<\/jats:styled-content>\n 2\/\n BIRC<\/jats:styled-content>\n ) is one of the most extensively characterized human\n IAP<\/jats:styled-content>\n . To date, no studies have focused on the expression level of\n cIAP<\/jats:styled-content>\n 2 in human gallbladder cancer (\n GBC<\/jats:styled-content>\n ), and the mechanism of\n cIAP<\/jats:styled-content>\n 2 in\n GBC<\/jats:styled-content>\n invasion and lymphangiogenesis remains unclear. Therefore, in the present study,\n cIAP<\/jats:styled-content>\n 2 expression in\n GBC<\/jats:styled-content>\n was detected using quantitative real\u2010time polymerase chain reaction and immunohistochemistry, and the relationship between\n cIAP<\/jats:styled-content>\n 2 levels in cancer tissues and the clinicopathological characteristics of patients was analyzed. The biological effect of\n cIAP<\/jats:styled-content>\n 2 in\n GBC<\/jats:styled-content>\n cells was tested using the Cell Counting Kit\u20108 Assay, Transwell assays and the ability of human dermal lymphatic endothelial cells (\n HDLEC<\/jats:styled-content>\n ) to undergo tube formation. The role of\n cIAP<\/jats:styled-content>\n 2 in activating the\n NF<\/jats:styled-content>\n \u2010\u03baB pathway was determined using a dual\u2010luciferase reporter assay, immunofluorescence staining, western blotting and\n ELISA<\/jats:styled-content>\n . Finally, an animal model was used to further confirm the role of\n cIAP<\/jats:styled-content>\n 2 in lymphangiogenesis. We showed that\n cIAP<\/jats:styled-content>\n 2 expression was elevated in human\n GBC<\/jats:styled-content>\n tissues and correlated with a negative prognosis for patients. Moreover,\n cIAP<\/jats:styled-content>\n 2 was identified as a lymphangiogenic factor of\n GBC<\/jats:styled-content>\n cells and, thus, promoted lymph node metastasis in\n GBC<\/jats:styled-content>\n cells. Our study is the first to suggest that\n cIAP<\/jats:styled-content>\n 2 can promote\n GBC<\/jats:styled-content>\n invasion and lymphangiogenesis by activating the NF\u2010\u03baB pathway.\n <\/jats:p>","DOI":"10.1111\/cas.13236","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T04:22:46Z","timestamp":1489551766000},"page":"1144-1156","source":"Crossref","is-referenced-by-count":34,"title":["cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF\u2010\u03baB pathway"],"prefix":"10.1111","volume":"108","author":[{"given":"Xiaojie","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fujian Medical University Fuzhou China"},{"name":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumour Microbiology The School of Basic Medical Sciences Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fujian Medical University Fuzhou China"},{"name":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumour Microbiology The School of Basic Medical Sciences Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fujian Medical University Fuzhou China"},{"name":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumour Microbiology The School of Basic Medical Sciences Fujian Medical University 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