{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:15:44Z","timestamp":1781626544358,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T00:00:00Z","timestamp":1497052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T00:00:00Z","timestamp":1497052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500460"],"award-info":[{"award-number":["81500460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2014ZSQN35"],"award-info":[{"award-number":["2014ZSQN35"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Gastric cancer (\n GC<\/jats:styled-content>\n ) is one of the most common malignancies, and cancer invasion and metastasis are the leading causes of cancer\u2010induced death in\n GC<\/jats:styled-content>\n patients.\n WASP<\/jats:styled-content>\n \u2010family verprolin\u2010homologous protein\u20102 (\n WASF<\/jats:styled-content>\n 2), with a role controlling actin polymerization which is critical in the formation of membrane protrusions involved in cell migration and invasion, has been reported to possess cancer\u2010promoting effects in several cancers. However, data of\n WASF<\/jats:styled-content>\n 2's role in\n GC<\/jats:styled-content>\n are relatively few and even contradictory. In this study, we analyzed\n WASF<\/jats:styled-content>\n 2 expression in\n GC<\/jats:styled-content>\n tissues and their corresponding adjacent normal tissues. We found that\n WASF<\/jats:styled-content>\n 2 was upregulated in\n GC<\/jats:styled-content>\n tissues and high level of\n WASF<\/jats:styled-content>\n 2 was associated with lymph node metastasis of\n GC<\/jats:styled-content>\n . Through gain\u2010 and loss\u2010of\u2010function studies,\n WASF<\/jats:styled-content>\n 2 was shown to significantly increase\n GC<\/jats:styled-content>\n cells migration and invasion, but had no effect on proliferation\n in vitro<\/jats:italic>\n . Importantly,\n WASF<\/jats:styled-content>\n 2 was also found to enhance\n GC<\/jats:styled-content>\n metastasis\n in vivo<\/jats:italic>\n . Our previous research suggested that\n \n WASF<\/jats:styled-content>\n 2\n <\/jats:italic>\n was a direct target of micro\n RNA<\/jats:styled-content>\n \u2010146a (miR\u2010146a). Furthermore, we analyzed miR\u2010146a's level in\n GC<\/jats:styled-content>\n tissues and their corresponding adjacent normal tissues. We found that miR\u2010146a was downregulated in\n GC<\/jats:styled-content>\n tissues and low miR\u2010146a level was associated with advanced\n TNM<\/jats:styled-content>\n stage and lymph node metastasis. The level of\n WASF<\/jats:styled-content>\n 2 in\n GC<\/jats:styled-content>\n tissues was negatively correlated with miR\u2010146a expression and had inverse clinicopathologic features. The newly identified miR\u2010146a\/\n WASF<\/jats:styled-content>\n 2 axis may provide a novel therapeutic target for\n GC<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/cas.13254","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T11:47:41Z","timestamp":1491565661000},"page":"1285-1292","source":"Crossref","is-referenced-by-count":8,"title":["RETRACTED: Clinicopathological significance of the micro\n RNA<\/scp>\n \u2010146a\/\n WASP<\/scp>\n \u2010family verprolin\u2010homologous protein\u20102 axis in gastric cancer"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3586-1911","authenticated-orcid":false,"given":"Qunyan","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuncai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 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