{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:36:55Z","timestamp":1791848215193,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in the head and neck treated with carbon\u2010ion radiotherapy. Data from 26 patients who underwent carbon\u2010ion radiotherapy in four facilities were analyzed in this multi\u2010institutional retrospective study: the Japan Carbon\u2010ion Radiation Oncology Study Group. The median follow\u2010up time was 34 months. One patient experienced local recurrence, and the 3\u2010year local control rate was 95%. One patient developed lymph node recurrence and five developed distant metastases. The 3\u2010year progression\u2010free survival rate was 73%. Five patients died, two of mucoepidermoid carcinoma and three of intercurrent disease. The 3\u2010year overall survival rate was 89%. Acute mucositis and dermatitis of grade 3 or higher were experienced by 19% and 8% of patients, respectively; these improved with conservative therapy. Late mucositis and osteonecrosis of jaw were observed in 12% and 23% of patients, respectively. The 3\u2010year cumulative rate of any late adverse event of grade 3 or higher was 14%. None of the patients died of the acute or late adverse events. Carbon\u2010ion radiotherapy was efficacious and safe for treating mucoepidermoid carcinoma in this multi\u2010institutional retrospective study (registration no.\n                    <jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\n                    000024473). We are currently undertaking a prospective multicenter study.\n                  <\/jats:p>","DOI":"10.1111\/cas.13270","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T07:48:33Z","timestamp":1493970513000},"page":"1447-1451","source":"Crossref","is-referenced-by-count":31,"title":["Multi\u2010institutional retrospective study of mucoepidermoid carcinoma treated with carbon\u2010ion radiotherapy"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-8847","authenticated-orcid":false,"given":"Katsuyuki","family":"Shirai","sequence":"first","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Koto","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4465-4300","authenticated-orcid":false,"given":"Yusuke","family":"Demizu","sequence":"additional","affiliation":[{"name":"Department of Radiology Hyogo Ion Beam Medical Center Tatsuno Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Suefuji","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA HIMAT Foundation Tosu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Okimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology Hyogo Ion Beam Medical Center Tatsuno Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Shioyama","sequence":"additional","affiliation":[{"name":"Ion Beam Therapy Center SAGA HIMAT Foundation Tosu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Gunma University Heavy Ion Medical Center Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kamada","sequence":"additional","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Japan Carbon\u2010Ion Radiation Oncology Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02870.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3053-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1217::AID-CNCR2>3.0.CO;2-C"},{"key":"e_1_2_7_5_1","first-page":"490","article-title":"Mucoepidermoid carcinoma: review of 815 reported cases","volume":"28","author":"Eversole LR","year":"1970","journal-title":"J Oral Surg"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2012.03.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00544-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.05.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.09.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-89"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.02.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.042"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90233-L"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.08.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0657-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.11.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.298"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141734"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-92"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20327"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29890"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.04.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-4-19"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23647"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8612"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.07.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12488"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.13270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.13270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.13270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:42:22Z","timestamp":1770115342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.13270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,29]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/cas.13270"],"URL":"https:\/\/doi.org\/10.1111\/cas.13270","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,29]]}}}