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The liver is a dominant metastatic site for patients with colorectal cancer. Molecular mechanisms that allow colorectal cancer cells to form liver metastases are largely unknown. Activation of epithelial\u2013mesenchymal transition is the key step for metastasis of cancer cells. We recently reported that dual\u2010specificity tyrosine\u2010regulated kinase 2 (<jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2) controls epithelial\u2013mesenchymal transition in breast cancer and ovarian serous adenocarcinoma. The aim of this study is to clarify whether <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2 regulates liver metastases of colorectal cancer. We show that the ability of cell invasion and migration was abrogated in <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2\u2010overexpressing cells. In an <jats:italic>in\u00a0vivo<\/jats:italic> xenograft model, liver metastatic lesions were markedly diminished by ectopic expression of <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2. Furthermore, we found that patients whose liver metastases expressed low <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2 levels had significantly worse overall and disease\u2010free survival. Given the findings that <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2 regulates cancer cell metastasis, we concluded that the expression status of <jats:styled-content style=\"fixed-case\">DYRK<\/jats:styled-content>2 could be a predictive marker for liver metastases of colorectal cancer.<\/jats:p>","DOI":"10.1111\/cas.13280","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T07:25:13Z","timestamp":1494746713000},"page":"1565-1573","source":"Crossref","is-referenced-by-count":31,"title":["Dual\u2010specificity tyrosine\u2010regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer"],"prefix":"10.1111","volume":"108","author":[{"given":"Daisuke","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Biochemistry Jikei University School of Medicine Tokyo Japan"},{"name":"Department of Surgery Jikei University School of Medicine Tokyo 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