{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:43:27Z","timestamp":1773675807692,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"US National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Although a number of previous studies have noted either positive or no association for body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and gastric cancer risk, little evidence exists in the Chinese population. We prospectively examined the associations of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> with risk of gastric cancer in the Linxian General Population Trial cohort, with 29\u00a0584 healthy adults enrolled in 1985 and followed through to the end of 2014. Body weight and height were measured during physical examination at baseline and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was calculated as weight in kilograms divided by height in meters squared. Body mass index from 138 subjects was missing, and a total of 29\u00a0446 participants were included in the final analysis. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. During 30\u00a0years of follow\u2010up, we confirmed 1716 newly diagnosed gastric cardia adenocarcinoma (<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>) cases and 626 new gastric non\u2010cardia adenocarcinoma (<jats:styled-content style=\"fixed-case\">GNCA<\/jats:styled-content>) cases. Overall, compared to the lowest quartile (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;20.32\u00a0kg\/m<jats:sup>2<\/jats:sup>), subjects in the fourth quartile (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226523.31\u00a0kg\/m<jats:sup>2<\/jats:sup>) subjects had lower risk of developing <jats:styled-content style=\"fixed-case\">GNCA<\/jats:styled-content> (hazard ratio, 0.65; 95% confidence interval, 0.51\u20130.83). Age\u2010 and sex\u2010specific analyses showed that this protective effect was only observed in men and older (52\u00a0+\u00a0years) persons. No associations were observed for <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> incidence. Higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was associated with decreased risk of <jats:styled-content style=\"fixed-case\">GNCA<\/jats:styled-content> in this population, particularly in men and older persons. Future studies are needed to confirm these findings. The trial is registered with ClinicalTrials.gov: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00342654.<\/jats:p>","DOI":"10.1111\/cas.13292","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T14:33:19Z","timestamp":1496932399000},"page":"1667-1672","source":"Crossref","is-referenced-by-count":24,"title":["Body mass index and risk of gastric cancer: A 30\u2010year follow\u2010up study in the Linxian general population trial cohort"],"prefix":"10.1111","volume":"108","author":[{"given":"Jin\u2010hu","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology Cancer Institute\/Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-2174","authenticated-orcid":false,"given":"Jian\u2010bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department 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College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000290"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22157"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.116665"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300551"},{"key":"e_1_2_7_10_1","first-page":"481","article-title":"Body mass index and the risk of cancers of the gastric cardia and distal stomachin Shanghai, 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