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However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechanisms of angiosarcoma progression, we collected 85\u00a0cases of human angiosarcoma specimens with clinical records and analyzed <jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HAS<\/jats:styled-content>\u2010B patient\u2010derived angiosarcoma cells. As control subjects, 54\u00a0cases of hemangioma and 34 of pyogenic granuloma were collected. Remarkably, consistent with our recent observations regarding the involvement of survivin expression following Hippo pathway inactivation in the neoplastic proliferation of murine hemangioendothelioma cells and human infantile hemangioma, nuclear survivin expression was observed in all cases of angiosarcoma but not in hemangiomas and pyogenic granulomas, and the Hippo pathway was inactivated in 90.3% of yes\u2010associated protein (<jats:styled-content style=\"fixed-case\">YAP<\/jats:styled-content>) \u2010positive angiosarcoma cases. However, survivin expression modes and <jats:styled-content style=\"fixed-case\">YAP<\/jats:styled-content> localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) transfection and <jats:styled-content style=\"fixed-case\">YM<\/jats:styled-content>155, an anti\u2010survivin drug, elicited decreased nuclear survivin expression and cell proliferation in <jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HAS<\/jats:styled-content>\u2010B cells which expressed survivin consistently. Conclusively, these findings support the importance of survivin as a good marker and critical regulator of cellular proliferation for human angiosarcoma and <jats:styled-content style=\"fixed-case\">YM<\/jats:styled-content>155 as a potential therapeutic agent.<\/jats:p>","DOI":"10.1111\/cas.13379","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T08:42:38Z","timestamp":1503909758000},"page":"2295-2305","source":"Crossref","is-referenced-by-count":24,"title":["Survivin: A novel marker and potential therapeutic target for human angiosarcoma"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3409-5485","authenticated-orcid":false,"given":"Masayuki","family":"Tsuneki","sequence":"first","affiliation":[{"name":"Division of Cancer Biology National Cancer Center Research Institute Tokyo Japan"},{"name":"Division of Pathology Department of Oral Diagnostic Sciences School of Dentistry Showa University Tokyo 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