{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:13:16Z","timestamp":1790820796720,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T00:00:00Z","timestamp":1507420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010GanRinsho\u2010Ippan\u2010020"],"award-info":[{"award-number":["H23\u2010GanRinsho\u2010Ippan\u2010020"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26\u2010GanSeisaku\u2010Ippan\u2010006"],"award-info":[{"award-number":["H26\u2010GanSeisaku\u2010Ippan\u2010006"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ck0106338h0001"],"award-info":[{"award-number":["17ck0106338h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Adult T\u2010cell leukemia\u2013lymphoma (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>) is a mature T\u2010cell malignancy associated with human T\u2010cell leukemia virus type 1 (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101) infection. Japan is the most endemic country for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> in the world. Recent nationwide studies of Japanese blood donors reported that <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 carriers spread from endemic areas to non\u2010endemic areas. Therefore, the latest information on nationwide epidemiological and clinical data for <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> is necessary to guide clinical practice. We undertook a multicenter, hospital\u2010based survey of newly diagnosed <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> patients from 2010 to 2011. A total of 996 patients with <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> were registered from 126 hospitals across Japan. Of those, 922 (487 men and 435 women) were included in the analysis. The median age at diagnosis was 68 years (interquartile range, 60\u201375 years). Overall, 67.2% of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> was diagnosed in the Kyushu\u2013Okinawa area. The most common subtype was acute (49.5%), followed by lymphoma (25.7%), chronic (14.2%), and smoldering (10.6%). Lymphoma type was more prevalent in men (60%), whereas chronic was more prevalent in women (60%). Half of patients with lymphoma type were aged over 70 years, whereas one\u2010third of patients with the chronic type were aged under 60 years. All of these characteristics were different from those of the previous nationwide surveys in the 1980s and 1990s. This survey clarified that half of current patients with <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> are aged over 68 years who were unable to receive intensive cytotoxic therapies. New less toxic agents for aged patients and further strategies to prevent the development of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 carrier status are needed.<\/jats:p>","DOI":"10.1111\/cas.13398","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:58:47Z","timestamp":1505375927000},"page":"2478-2486","source":"Crossref","is-referenced-by-count":78,"title":["Epidemiological and clinical features of adult T\u2010cell leukemia\u2013lymphoma in Japan, 2010\u20132011: A nationwide survey"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-2451","authenticated-orcid":false,"given":"Kisato","family":"Nosaka","sequence":"first","affiliation":[{"name":"Department of Hematology Kumamoto University School of Medicine Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Frontier Life Science Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Hematology Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Division of Hematology and Immunology Center for Chronic Viral Diseases Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Iwate Medical University Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-0777","authenticated-orcid":false,"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naokuni","family":"Uike","sequence":"additional","affiliation":[{"name":"Department of Palliative Care Saga\u2010ken Medical Center Koseikan Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura General Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical Innovation St. Marianna University Graduate School of Medicine Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Uchimaru","sequence":"additional","affiliation":[{"name":"Graduate School of Frontier Sciences The University of Tokyo Tokyo 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