{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:12:19Z","timestamp":1779142339925,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006327","name":"National Institute of Radiological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The treatment outcomes of patients with high\u2010risk localized prostate cancer (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) after carbon\u2010ion radiotherapy (<jats:styled-content style=\"fixed-case\">CIRT<\/jats:styled-content>) combined with long\u2010term androgen deprivation therapy (<jats:styled-content style=\"fixed-case\">LTADT<\/jats:styled-content>) were analyzed, and compared with those of other treatment modalities, focusing on <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\u2010specific mortality (<jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content>). A total of 1247 patients were enrolled in three phase\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> clinical trials of fixed\u2010dose <jats:styled-content style=\"fixed-case\">CIRT<\/jats:styled-content> between 2000 and 2013. Excluding patients with T4 disease, 608 patients with high\u2010risk or very\u2010high\u2010risk <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>, according to the National Comprehensive Cancer Network classification system, who received <jats:styled-content style=\"fixed-case\">CIRT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">LTADT<\/jats:styled-content> were evaluated. The median follow\u2010up time was 88.4\u00a0months, and the 5\u2010\/10\u2010year <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> rates were 1.5%\/4.3%, respectively. T3b disease, Gleason score of 9\u201310 and percentage of positive biopsy cores &gt;75% were associated with significantly higher <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> on univariate and multivariate analyses. The 10\u2010year <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> rates of patients having all three (<jats:italic>n<\/jats:italic>\u00a0=\u00a016), two (<jats:italic>n<\/jats:italic>\u00a0=\u00a074) or one of these risk factors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0217) were 27.1, 11.6 and 5.7%, respectively. Of the 301 patients with none of these factors, only 1 <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> occurred over the 10\u2010year follow\u2010up (10\u2010year <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> rate, 0.3%), and significant differences were observed among the four stratified groups (<jats:italic>P<\/jats:italic>\u00a0&lt;0.001). <jats:styled-content style=\"fixed-case\">CIRT<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">LTADT<\/jats:styled-content> yielded relatively favorable treatment outcomes in patients with high\u2010risk <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> and very favorable results in patients without any of the three abovementioned factors for <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content>. Because a significant difference in <jats:styled-content style=\"fixed-case\">PCSM<\/jats:styled-content> among the high\u2010risk <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> patient groups was observed, new categorization and treatment intensity adjustment may be required for high\u2010risk <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">CIRT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.13402","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:12:50Z","timestamp":1505743970000},"page":"2422-2429","source":"Crossref","is-referenced-by-count":24,"title":["Cancer\u2010specific mortality of high\u2010risk prostate cancer after carbon\u2010ion radiotherapy plus long\u2010term androgen deprivation 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