{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:06:44Z","timestamp":1790698004456,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,1]]},"abstract":"The CXCR<\/jats:styled-content>4\/CXCR<\/jats:styled-content>7\/CXCL<\/jats:styled-content>12 chemokine axis plays important roles in the migration of tumor cells during cancer development by modulating site\u2010specific distant metastasis including to regional lymph nodes. We investigated the correlation of these chemokine expressions to prognosis in lymph\u2010node\u2010positive non\u2010small\u2010cell lung cancer (NSCLC<\/jats:styled-content>) patients. A total of 140 surgically resected specimens of primary site (PS<\/jats:styled-content>) and metastatic lymph nodes (MLN<\/jats:styled-content>) of NSCLC<\/jats:styled-content> involving hilar and\/or mediastinal lymph nodes (N1\u20102) were collected. CXCR<\/jats:styled-content>4, CXCR<\/jats:styled-content>7 and CXCL<\/jats:styled-content>12 expressions were evaluated. Cox regression analysis was performed to determine whether these chemokines were independent prognostic factors in N1\u20102 NSCLC<\/jats:styled-content>. High expression of CXCR<\/jats:styled-content>4 in PS<\/jats:styled-content> and CXCL<\/jats:styled-content>12 in MLN<\/jats:styled-content> was associated with poor overall survival (OS<\/jats:styled-content>) (P<\/jats:italic> = .025 and .033, respectively). Significant correlations between CXCR<\/jats:styled-content>4 expression in PS<\/jats:styled-content> and CXCL<\/jats:styled-content>12 expression in MLN<\/jats:styled-content> were observed (P<\/jats:italic> = .040). There was significant difference in OS<\/jats:styled-content> between 2 groups according to expressions of CXCR<\/jats:styled-content>4 in PS<\/jats:styled-content> and CXCL<\/jats:styled-content>12 in MLN<\/jats:styled-content> (P<\/jats:italic> = .0033). Expression of CXCL<\/jats:styled-content>12 in MLN<\/jats:styled-content> was identified as an independent prognostic factor (HR<\/jats:styled-content> 1.79, 95% CI<\/jats:styled-content> 1.08\u20103.04, P<\/jats:italic> = .023). CXCL<\/jats:styled-content>12 in MLN<\/jats:styled-content> was mainly expressed by tumor cells compared with stromal cells (56% vs<\/jats:italic> 25%, respectively, P<\/jats:italic> < .0001). CXCR<\/jats:styled-content>4\/CXCL<\/jats:styled-content>12 may play roles in tumor progression in MLN<\/jats:styled-content> and is associated with poor prognosis of lymph\u2010node\u2010positive NSCLC<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/cas.13422","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T09:06:40Z","timestamp":1508058400000},"page":"154-165","source":"Crossref","is-referenced-by-count":38,"title":["Correlation between CXCR4\/CXCR7\/CXCL12 chemokine axis expression and prognosis in lymph\u2010node\u2010positive lung cancer patients"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-1768","authenticated-orcid":false,"given":"Masakazu","family":"Katsura","sequence":"first","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka 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