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The purpose of the present study was to determine the clinical significance of Trp catabolism in newly diagnosed Hodgkin lymphoma (HL) patients. We quantified serum Trp and Kyn in 52 HL patients, and analyzed their associations with different clinical parameters including serum soluble CD30 concentration. The IDO expression was evaluated in the patients\u2019 affected lymph nodes. The cohort comprised 22 male and 30 female patients (age range, 15\u201081\u00a0years; median, 45\u00a0years), with a 5\u2010year overall survival (OS) of 88.6%. The OS was significantly shorter for patients with a high Kyn\/Trp ratio (OS at 5\u00a0years, 60.0% vs 92.2%), for those with stage IV disease, and for those with lymphocytopenia (&lt;600\/mm<jats:sup>3<\/jats:sup> and\/or &lt;8% white blood cell count). The latter two parameters are components of the international prognostic score for advanced HL. In contrast, there were no significant differences in OS according to age, serum albumin, hemoglobin, sex, white blood cell count, or serum soluble CD30 (\u2265 or &lt;285.6\u00a0ng\/mL). Multivariate analysis using the three variables stage, lymphocytopenia, and serum Kyn\/Trp ratio showed that only the latter significantly affected OS. Indoleamine 2,3\u2010dioxygenase 1 was produced by macrophages\/dendritic cells, but not by HL tumor cells, and IDO levels determined by immunohistochemistry had a significant positive correlation with the serum Kyn\/Trp ratio. In conclusion, quantification of serum Kyn and Trp is useful for predicting prognosis of individual HL patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cas.13432","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T15:32:37Z","timestamp":1509204757000},"page":"74-83","source":"Crossref","is-referenced-by-count":28,"title":["Clinical significance of tryptophan catabolism in Hodgkin lymphoma"],"prefix":"10.1111","volume":"109","author":[{"given":"Ayako","family":"Masaki","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"},{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya 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