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To assess the clinical features, outcomes, and prognostic factors of this disease, we retrospectively analyzed 185 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients from four medical centers in southern China. The median age was 37\u00a0years. One hundred and twenty\u2010one patients (65.4%) were classified as unicentric <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">UCD<\/jats:styled-content>) and 64 patients (34.6%) were classified as multicentric <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>). The histology subtype was hyaline\u2010vascular for 132 patients (71.4%), plasma cell for 50 patients (27%), and mixed type for 3 patients (1.6%). The 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) of 185 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cases was 80.3%. All <jats:styled-content style=\"fixed-case\">UCD<\/jats:styled-content> patients underwent surgical excision, whereas the treatment strategies of <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> patients were heterogeneous. The outcome for <jats:styled-content style=\"fixed-case\">UCD<\/jats:styled-content> patients was better than <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> patients, with 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates of 93.6% and 51.2%, respectively. In further analysis of the <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> subgroup, a multivariate analysis using a Cox regression model revealed that age, splenomegaly and pretreatment serum albumin level were independent prognostic factors for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. This multicenter study comprising the largest sample size to date suggested that <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> is a distinct entity from <jats:styled-content style=\"fixed-case\">UCD<\/jats:styled-content> with a significantly worse outcome. Older age (\u226540\u00a0years), splenomegaly, and hypoalbuminemia were risk factors for poorer <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> prognosis.<\/jats:p>","DOI":"10.1111\/cas.13439","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T01:02:37Z","timestamp":1510275757000},"page":"199-206","source":"Crossref","is-referenced-by-count":56,"title":["Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients"],"prefix":"10.1111","volume":"109","author":[{"given":"Xuanye","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Sun 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