{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:52:49Z","timestamp":1781977969309,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24592014"],"award-info":[{"award-number":["24592014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K10176"],"award-info":[{"award-number":["15K10176"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Multimodality therapies are used to manage patients with hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>), although advanced <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> is incurable. Oncolytic virus therapy is probably the next major breakthrough in cancer treatment. The third\u2010generation oncolytic herpes simplex virus type 1 (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101) T\u201001 kills tumor cells without damaging the surrounding normal tissues. Here we investigated the antitumor effects of T\u201001 on <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and the host's immune response to <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> cells. The cytopathic activities of T\u201001 were tested in 14 human and 1 murine hepatoma cell line in vitro. In various mouse xenograft models, HuH\u20107, <jats:styled-content style=\"fixed-case\">KYN<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">PLC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/5 and HepG2 human cells and Hepa1\u20106 murine cells were used to investigate the in vivo efficacy of T\u201001. T\u201001 was cytotoxic to 13 cell lines (in vitro). In mouse xenograft models of subcutaneous, orthotopic and peritoneal tumor metastasis in athymic mice (<jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c nu\/nu), the growth of tumors formed by the human <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> cell lines and hepatoblastoma cell line was inhibited by T\u201001 compared with that of mock\u2010inoculated tumors. In a bilateral Hepa1\u20106 subcutaneous tumor model in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice, the growth of tumors inoculated with T\u201001 was inhibited, as was the case for contralateral tumors. T\u201001 also significantly reduced tumor growth. T\u201001 infection significantly enhanced antitumor efficacy via T cell\u2010mediated immune responses. Results demonstrate that a third\u2010generation oncolytic <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101 may serve as a novel treatment for patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.13492","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T07:16:42Z","timestamp":1514618202000},"page":"600-610","source":"Crossref","is-referenced-by-count":27,"title":["Third\u2010generation oncolytic herpes simplex virus inhibits the growth of liver tumors in mice"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-9570","authenticated-orcid":false,"given":"Richi","family":"Nakatake","sequence":"first","affiliation":[{"name":"Department of Surgery Kansai Medical University Hirakata, Osaka 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Advanced Clinical Research Center The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kon","sequence":"additional","affiliation":[{"name":"Department of Surgery Kansai Medical University Hirakata, Osaka 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