{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:17Z","timestamp":1787013977471,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470346"],"award-info":[{"award-number":["81470346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730003"],"award-info":[{"award-number":["81730003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773361"],"award-info":[{"award-number":["81773361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Jiangsu Science and Technology Department","doi-asserted-by":"publisher","award":["BL2012005"],"award-info":[{"award-number":["BL2012005"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161204"],"award-info":[{"award-number":["BK20161204"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    The aim of this study is to investigate the potential biomarkers associated with chronic myeloid leukemia (\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    ), reveal the metabolite changes related to the continuous phases of tyrosine kinase inhibitors (\n                    <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>\n                    s), and find the potential biomarkers associated with treatment effects. Fifty\u2010two patients with\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    and 26 matched healthy people were enrolled as the discovery set. Another 194 randomly selected\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    patients treated with\n                    <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>\n                    were chosen as the external validation set. Plasma samples from the patients and controls were profiled using the gas chromatography\u2010mass spectrometry\u2010based metabonomic approach. Multivariate and univariate statistical analyses were combined to select the differential metabolic features. The gas chromatography\u2010mass spectrometry\u2010based metabolomics showed a clear clustering and separation of metabolic patterns from healthy controls and pre\u2010 and post\u2010\n                    <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>\n                    treatment\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    patients in the discovery set. We identified 9 metabolites that differentiated\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    patients from healthy controls, including lactic acid, isoleucine, glycerol, glycine, myristic acid,\n                    <jats:sc>d<\/jats:sc>\n                    \u2010sorbitol,\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose,\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glucose, and myo\u2010inositol. Among the 9 markers, glycerol and myristic acid had the most significant association with\n                    <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>\n                    treatment effects in both discovery and external validation sets. In the receiver operating characteristic analysis, the combination of glycerol and myristic acid showed a better discrimination performance compared to a single biomarker. The results indicated that metabolic profiling has the potential for diagnosis of\n                    <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\n                    and the panel of biomarkers including myristic acid and glycerol could be useful in monitoring\n                    <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>\n                    therapeutic responses.\n                  <\/jats:p>","DOI":"10.1111\/cas.13500","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T03:55:56Z","timestamp":1515556556000},"page":"777-784","source":"Crossref","is-referenced-by-count":21,"title":["Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-5707","authenticated-orcid":false,"given":"Bingyu","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University Suzhou China"},{"name":"Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Xie","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University Suzhou China"},{"name":"Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University Suzhou China"},{"name":"Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depei","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University Suzhou China"},{"name":"Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology Suzhou 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