{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:51:02Z","timestamp":1789861862261,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Peripheral T\u2010 or natural killer (NK<\/jats:styled-content>)\u2010cell lymphomas are rare and difficult\u2010to\u2010recognize diseases. It remains arduous to distinguish between NK<\/jats:styled-content> cell\u2010 and cytotoxic T\u2010lymphocyte\u2010derived lymphomas through routine histological evaluation. To clarify the cells of origin, we focused on NK<\/jats:styled-content>\u2010cell receptors and examined the expression using immunohistochemistry in 22 cases with T\u2010 and NK<\/jats:styled-content>\u2010cell neoplasms comprising angioimmunoblastic T\u2010cell lymphoma, anaplastic lymphoma kinase (ALK<\/jats:styled-content>)\u2010positive and \u2010negative anaplastic large\u2010cell lymphomas, extranodal NK<\/jats:styled-content>\/T\u2010cell lymphoma, nasal type, monomorphic epitheliotropic intestinal T\u2010cell lymphoma, aggressive NK<\/jats:styled-content>\u2010cell leukemia, and other peripheral T\u2010cell lymphomas. Inhibitory receptor leukocyte immunoglobulin\u2010like receptor subfamily B member 1 (LILRB<\/jats:styled-content>1) was detected in 14 (64%) cases, whereas activating receptors DNAM<\/jats:styled-content>1, NK<\/jats:styled-content>p46, and NKG<\/jats:styled-content>2D were expressed in 7 (32%), 9 (41%), and 5 (23%) cases, respectively. Although LILRB<\/jats:styled-content>1 was detected regardless of the disease entity, the activating NK<\/jats:styled-content>\u2010cell receptors were expressed predominantly in TIA<\/jats:styled-content>\u20101\u2010positive neoplasms (DNAM<\/jats:styled-content>1, 49%; NK<\/jats:styled-content>p46, 69%; and NKG<\/jats:styled-content>2D, 38%). In addition, NK<\/jats:styled-content>p46 and NKG<\/jats:styled-content>2D were detected only in NK<\/jats:styled-content>\u2010cell neoplasms and cytotoxic T\u2010lymphocyte\u2010derived lymphomas including monomorphic epitheliotropic intestinal T\u2010cell lymphoma. One Epstein\u2010Barr virus\u2010harboring cytotoxic T\u2010lymphocyte\u2010derived lymphoma mimicking extranodal NK<\/jats:styled-content>\/T\u2010cell lymphoma, nasal type lacked these NK<\/jats:styled-content>\u2010cell receptors, indicating different cell origin from NK<\/jats:styled-content> and innate\u2010like T cells. Furthermore, NKG<\/jats:styled-content>2D expression showed a negative impact on survival among the 22 examined cases, which mainly received the standard chemotherapy regimen (log\u2010rank test, P<\/jats:italic>\u00a0=\u00a0.024). We propose that the presence of activating NK<\/jats:styled-content>\u2010cell receptors may provide new insights into understanding peripheral T\u2010cell lymphomas and characterizing them as innate\u2010like T\u2010cell neoplasm.<\/jats:p>","DOI":"10.1111\/cas.13512","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T06:23:07Z","timestamp":1516774987000},"page":"1254-1262","source":"Crossref","is-referenced-by-count":11,"title":["Expression of activating natural killer\u2010cell receptors is a hallmark of the innate\u2010like T\u2010cell neoplasm in peripheral T\u2010cell lymphomas"],"prefix":"10.1111","volume":"109","author":[{"given":"Yu","family":"Uemura","sequence":"first","affiliation":[{"name":"Division of Hematology & Oncology Department of Internal Medicine St. Marianna University School of Medicine Kawasaki 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