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The aim of the present study was to explore the specific effect of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035 on patient prognosis. Additionally, we formulated an effective prognostic nomogram for <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients after curative resection. Immunohistochemistry was applied to explore <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035 expression as well as <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035 receptor (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035R) in 102 <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients. Results showed that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035 was highly expressed in <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> tumor tissues and was positively associated with lymph node metastasis (<jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage and vascular invasion and was an independent prognostic factor for patients' overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content>). High expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035R (gp130 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012R\u03b22) was also observed in <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> cancer tissues, but only gp130 was an independent prognostic factor for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> and was indispensable in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035\u2010mediated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> clinical prognosis. The nomogram comprising carcinoembryonic antigen, <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u201035 and gp130 expression achieved better predictive accuracy compared with <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Our data support that high <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201035 expression correlates with <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> aggressiveness and emerges as a valuable biomarker for evaluating <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> progression and prognosis in clinical work.<\/jats:p>","DOI":"10.1111\/cas.13535","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:50:27Z","timestamp":1518702627000},"page":"1195-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Overexpression of interleukin\u201035 in intrahepatic cholangiocarcinoma is a prognostic indicator after curative 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