{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:26:49Z","timestamp":1785594409602,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>A retrospective multicenter study was carried out to assess the clinical outcomes of carbon\u2010ion radiotherapy for head and neck malignancies (Japan Carbon\u2010Ion Radiation Oncology Study Group [J\u2010<jats:styled-content style=\"fixed-case\">CROS<\/jats:styled-content>] study: 1402 <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>). We evaluated the safety and efficacy of carbon\u2010ion radiotherapy in patients with major salivary gland carcinoma. Sixty\u2010nine patients treated with carbon\u2010ion radiotherapy at four Japanese institutions were analyzed. Thirty\u2010three patients (48%) had adenoid cystic carcinomas, 10 (14%) had mucoepidermoid carcinomas, and 26 (38%) had other disease types. Three patients (4%) had T1 disease, 8 (12%) had T2, 25 (36%) had T3, and 33 (48%) had T4. The median radiation dose was 64\u00a0Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 27\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>. The median follow\u2010up period was 32.7\u00a0months. The 3\u2010year local control rate and overall survival rate were 81% and 94%, respectively. Regarding acute toxicities, seven patients had grade 3 mucositis and seven had grade 3 dermatitis. Regarding late toxicities, one patient had grade 3 dysphagia and one had a grade 3 brain abscess. No grade 4 or worse late reactions were observed. In conclusion, definitive carbon\u2010ion radiotherapy was effective with acceptable toxicity for major salivary gland carcinomas.<\/jats:p>","DOI":"10.1111\/cas.13558","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T14:52:59Z","timestamp":1519915979000},"page":"1576-1582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["A retrospective multicenter study of carbon\u2010ion radiotherapy for major salivary gland carcinomas: Subanalysis of J\u2010<scp>CROS<\/scp> 1402 <scp>HN<\/scp>"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-4629","authenticated-orcid":false,"given":"Kazuhiko","family":"Hayashi","sequence":"first","affiliation":[{"name":"Hospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Sciences and Technology Chiba 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