{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:25:12Z","timestamp":1770776712243,"version":"3.50.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Although cytology\u2010based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) testing for cervical screening increases detection of high\u2010grade cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>) and invasive cancer. However, the optimal triage strategy for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive women to avoid over\u2010referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3\u2010year prospective study, <jats:styled-content style=\"fixed-case\">COM<\/jats:styled-content>parison of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotyping And Cytology Triage (<jats:styled-content style=\"fixed-case\">COMPACT<\/jats:styled-content>), to evaluate the potential role of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 partial genotyping and cytology for primary <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing were carried out. Women with abnormal cytology or <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 positivity underwent colposcopy. Those with 12 other high\u2010risk (hr) <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types underwent repeat cytology after 6 months. Primary study endpoints were detection of high\u2010grade cervical disease defined as <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\/<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HPV<\/jats:styled-content> 16, and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 were detected in all (8\/8) invasive cervical cancers and in all (2\/2) adenocarcinomas in situ. Both cytological abnormalities and hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010based screening program. Results should help policy\u2010makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype.<\/jats:p>","DOI":"10.1111\/cas.13608","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T23:34:36Z","timestamp":1523921676000},"page":"2003-2012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of human papillomavirus genotyping and cytology triage, <scp>COMPACT<\/scp> Study: Design, methods and baseline results in 14 642 women"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-9593","authenticated-orcid":false,"given":"Satomi","family":"Aoyama\u2010Kikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine Sapporo 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