{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:57:35Z","timestamp":1787241455797,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260312"],"award-info":[{"award-number":["81260312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n This research aimed to analyze the effect of\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n on the radioresistance of oral neoplasm. Using a multi\u2010group heat map from GSE9716 analysis of the GEO database,\n IFITM1<\/jats:italic>\n was determined to be a relevant radioresistance gene. The TCGA database was analyzed before the expression of\n IFITM1<\/jats:italic>\n was analyzed.\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression was quantified by quantitative\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n and immunohistochemistry in 19 paired oral neoplasm cases. The effects of time and dose of radiation on\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression level in\n CAL<\/jats:styled-content>\n 27 and\n TSCC<\/jats:styled-content>\n 1 cell lines were tested by quantitative\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n . Oral neoplasm cells were transfected with si\n RNA<\/jats:styled-content>\n after radiotherapy to disturb\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression. After this, the survival rates, cell apoptosis, caspase\u20103 viability, expression and \u03b3\u2010H2\n AX<\/jats:styled-content>\n were detected using colony formation, flow cytometry, western blot and immunofluorescence, respectively. Western blot was used for\n STAT<\/jats:styled-content>\n 1\/2\/3\/p21\u2010related protein and phosphorylation changes. Finally, an in\u00a0vivo nude mice tumor model was established to verify the effect of\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n on oral neoplasm cells radioresistance. Through microarray analysis, the head and neck neoplasm radioresistance\u2010related gene\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n was found to be overexpressed.\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n overexpression was verified not only using the\n TCGA<\/jats:styled-content>\n database but also in 19 paired cases of oral neoplasm tissues and cells. With increases of dose and time of radiation, the expression of\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n was increased in\n CAL<\/jats:styled-content>\n 27 and\n TSCC<\/jats:styled-content>\n 1 cell lines. Furthermore, si\u2010\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n may restrain cell proliferation,\n DNA<\/jats:styled-content>\n damage and cell apoptosis in oral neoplasm cell lines. Finally,\n pSTAT<\/jats:styled-content>\n 1\/2\/p21 was found to be upregulated while\n pSTAT<\/jats:styled-content>\n 3\/p\u2010p21 was downregulated due to\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n inhibition after radiotherapy. The evidence suggested that\n \n IFITM<\/jats:styled-content>\n 1\n <\/jats:italic>\n in combination with radiotherapy can inhibit oral neoplasm cells.\n <\/jats:p>","DOI":"10.1111\/cas.13640","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:49:07Z","timestamp":1526514547000},"page":"3115-3128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Combination of\n IFITM1<\/i>\n knockdown and radiotherapy inhibits the growth of oral cancer"],"prefix":"10.1111","volume":"109","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"},{"name":"The Affiliated Stomatological Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xi","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimei","family":"Sun","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Ren","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liufang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Radiation Therapy Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8487-0315","authenticated-orcid":false,"given":"Xiaojiang","family":"Li","sequence":"additional","affiliation":[{"name":"Head and Neck Tumor Research Center No. 3 Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province & Yunnan Cancer Center) Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_248_16"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01325"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4250"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.12.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v17i1.5677"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.10.026"},{"key":"e_1_2_6_8_1","first-page":"16007","article-title":"Prognostic significance of IFN\u2010induced transmembrane protein 1 in colorectal cancer","volume":"8","author":"He J","year":"2015","journal-title":"Int J Clin Exp 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