{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:10:40Z","timestamp":1772064640158,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) are extensively involved in various malignant tumors, including ovarian cancer (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>). In the present study, we focused on the expression and function of nuclear enriched abundant transcript 1 (<jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1) in <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> cells\u2019 metastasis. We demonstrated that <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 was upregulated in <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> tissue specimens and cell lines. In addition, we revealed that depression of <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 inhibited <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> cells\u2019 metastasis and the expression of Rho associated coiled\u2010coil containing protein kinase 1 (<jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1), which is a metastasis\u2010related gene. Using online predictive software and a series of luciferase assays, we demonstrated that both <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1 were the targets of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010382\u20103p (miR\u2010382\u20103p) and share similar micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> responding elements (<jats:styled-content style=\"fixed-case\">MRE<\/jats:styled-content>). Furthermore, we illustrated that <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 and miR\u2010382\u20103p inhibited each other in a reciprocal manner. Finally, through antisense experiments we demonstrated that <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 promoted <jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1\u2010mediated metastasis by functioning as a ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> of miR\u2010382\u20103p. In summary, the findings of this study revealed that <jats:styled-content style=\"fixed-case\">NEAT<\/jats:styled-content>1 promoted <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> cells\u2019 metastasis through regulating the miR\u2010382\u20103p\/<jats:styled-content style=\"fixed-case\">ROCK<\/jats:styled-content>1 axial. The present study might provide a new target for treating <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.13647","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T10:48:43Z","timestamp":1527072523000},"page":"2188-2198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Long non\u2010coding <scp>RNA NEAT<\/scp>1 promoted ovarian cancer cells\u2019 metastasis through regulation of miR\u2010382\u20103p\/<scp>ROCK<\/scp>1 axial"],"prefix":"10.1111","volume":"109","author":[{"given":"Yangcheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"4th Department of Orthopedic Surgery Central 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