{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:03:31Z","timestamp":1788462211979,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP15K19052"],"award-info":[{"award-number":["JP15K19052"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Nodal cytotoxic molecule (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>)\u2010positive peripheral T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>) has recently been recognized as a clinicopathologically distinct disease. To further characterize this disease, here we compared 58 patients with Epstein\u2010Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010negative <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content> to 48 patients with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>. The two groups did not differ in histopathology, T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) expression or rearrangement incidences, or survival curves. However, patients with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content> less frequently showed hepatic involvement (<jats:italic>P<\/jats:italic> = .007), B symptoms (<jats:italic>P<\/jats:italic> = .020), hemophagocytosis (<jats:italic>P<\/jats:italic> = .024), and detectable <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 (<jats:italic>P<\/jats:italic> = .002) and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 (<jats:italic>P<\/jats:italic> = .009). Univariate and multivariate analyses identified three factors that independently predicted favorable survival, onset age &lt;60 years (<jats:italic>P<\/jats:italic> = .002), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 expression (<jats:italic>P<\/jats:italic> = .002), and mixed morphology (<jats:italic>P<\/jats:italic> = .013), <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b1\u03b2 was not an independent predictor (<jats:italic>P<\/jats:italic> = .30), but was strongly linked with long survivorship among patients younger than 60 years old. A prognostic model incorporating these factors worked well for prognostic delineation, independently of the International Prognostic Index (<jats:italic>P<\/jats:italic> = .007 vs <jats:italic>P<\/jats:italic> = .082) and Prognostic Index for <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = .020 vs <jats:italic>P<\/jats:italic> = .15). Moreover, this constellation of findings indicated two nodal indolent diseases: <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b1\u03b2 (n = 13), and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\u2010cell type lacking <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> expression or clonal <jats:italic><jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content><\/jats:italic>\u03b3 rearrangement (n = 4). The survival curves for these two groups were significantly superior to others (n = 29, <jats:italic>P<\/jats:italic> &lt; .001). These diseases appear to be unique in their indolent clinical behavior, and should be managed differently from other diseases.<\/jats:p>","DOI":"10.1111\/cas.13652","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T06:56:20Z","timestamp":1527663380000},"page":"2599-2610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Reappraisal of nodal Epstein\u2010Barr Virus\u2010negative cytotoxic T\u2010cell lymphoma: Identification of indolent <scp>CD<\/scp>5<sup>+<\/sup> diseases"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-1794","authenticated-orcid":false,"given":"Daisuke","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-1276","authenticated-orcid":false,"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyata\u2010Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya 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