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We conducted a phase II<\/jats:styled-content> study of induction immunochemotherapy of R\u2010High\u2010CHOP<\/jats:styled-content>\/CHASER<\/jats:styled-content> followed by HDC<\/jats:styled-content> of LEED<\/jats:styled-content> with ASCT<\/jats:styled-content> in younger patients with untreated advanced MCL<\/jats:styled-content>. Eligibility criteria included untreated MCL<\/jats:styled-content>, stage II<\/jats:styled-content> bulky to IV<\/jats:styled-content>, and age 20\u201065 years. Patients received 1 cycle of R\u2010High\u2010CHOP<\/jats:styled-content> followed by 3 cycles of CHASER<\/jats:styled-content> every 3 weeks. Peripheral blood stem cells (PBSC<\/jats:styled-content>) were harvested during CHASER<\/jats:styled-content>. LEED<\/jats:styled-content> with ASCT<\/jats:styled-content> was delivered to patients who responded to R\u2010High\u2010CHOP<\/jats:styled-content>\/CHASER<\/jats:styled-content>. Primary endpoint was 2\u2010year progression\u2010free survival (PFS<\/jats:styled-content>). From June 2008 to June 2012, 45 patients (median age 59 years; range 38\u201065 years) were enrolled. PBSC<\/jats:styled-content> were successfully harvested from 36 of 43 patients. Thirty\u2010five patients completed ASCT<\/jats:styled-content>. Two\u2010year PFS<\/jats:styled-content> was 77% (80% CI<\/jats:styled-content> 68\u201084), which met the primary endpoint. Five\u2010year PFS<\/jats:styled-content> and overall survival were 52% (95% CI<\/jats:styled-content> 34\u201068%) and 71% (95% CI<\/jats:styled-content> 51\u201084%), respectively. Overall response and complete response rates after induction immunochemotherapy were 96% and 82%, respectively. The most common grade 4 toxicities were hematological. In younger patients with untreated MCL<\/jats:styled-content>, R\u2010High\u2010CHOP<\/jats:styled-content>\/CHASER<\/jats:styled-content>\/LEED<\/jats:styled-content> with ASCT<\/jats:styled-content> showed high efficacy and acceptable toxicity, and it can now be considered a standard treatment option.<\/jats:p>","DOI":"10.1111\/cas.13719","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T09:46:31Z","timestamp":1530265591000},"page":"2830-2840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["R\u2010High\u2010CHOP<\/scp>\/CHASER<\/scp>\/LEED<\/scp> with autologous stem cell transplantation in newly diagnosed mantle cell lymphoma: JCOG0406 STUDY"],"prefix":"10.1111","volume":"109","author":[{"given":"Michinori","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kasugai Municipal Hospital Kasugai Japan"},{"name":"Department of 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