{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:51:14Z","timestamp":1789872674931,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Fund","award":["No: Y18H200014"],"award-info":[{"award-number":["No: Y18H200014"]}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents","doi-asserted-by":"crossref","award":["No: 2012"],"award-info":[{"award-number":["No: 2012"]}],"id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Non\u2010small cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. Interaction between programmed death 1 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101) and its ligand, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1, plays important roles in tumor immunology. Follicular helper T (Tfh) cells have characteristically high <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression; thus, in the present study, we investigated the role of circulating Tfh cells and their correlation with disease\u2010free survival after tumor resection in <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>. We found significantly higher number of Tfh cells but lower serum interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201021 levels in <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients, especially in those with advanced stage (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>), indicating that the function of Tfh cells to produce <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 was impaired. Further analysis showed that the increase in Tfh cells was attributable to an expansion of the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101<jats:sup>+<\/jats:sup>\u2010Tfh2 and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101<jats:sup>+<\/jats:sup>\u2010Tfh17 subtypes. Functional analysis showed that Tfh cells from <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients induced the differentiation of regulatory B cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14<jats:sup>+<\/jats:sup> human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells. Interestingly, the number of Tfh1 subtypes in <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients was negatively correlated with disease\u2010free survival after tumor resection. In short, the high number and abnormal function of Tfh cells could cause further immunosuppression and lead to tumor development in <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>. Rescuing Tfh functions therefore represents a potential therapeutic strategy in <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.13836","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T13:13:26Z","timestamp":1539695606000},"page":"3751-3761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Functionally impaired follicular helper T cells induce regulatory B cells and <scp>CD<\/scp>14<sup>+<\/sup> human leukocyte antigen\u2010<scp>DR<\/scp><sup>\u2212<\/sup> cell differentiation in non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-8391","authenticated-orcid":false,"given":"Liannv","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Zhejiang Provincial People's Hospital People's Hospital of Hangzhou Medical College 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