{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:09:31Z","timestamp":1781363371213,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H04774"],"award-info":[{"award-number":["15H04774"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Occupational asbestos exposure occurs in many workplaces and is a well\u2010known cause of mesothelioma and lung cancer. However, the association between nonoccupational asbestos exposure and those diseases is not clearly described. The aim of this study was to investigate cause\u2010specific mortality among the residents of Amagasaki, a city in Japan with many asbestos factories, and evaluate the potential excess mortality due to established and suspected asbestos\u2010related diseases. The study population consisted of 143\u00a0929 residents in Amagasaki City before 1975 until 2002, aged 40\u00a0years or older on January 1, 2002. Follow\u2010up was carried out from 2002 to 2015. Standardized mortality ratio (<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>) with its 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) was calculated by sex, using the mortality rate of the Japanese population as reference. A total of 38\u00a0546 deaths (including 303 from mesothelioma and 2683 from lung cancer) were observed. The <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>s in the long\u2010term residents\u2019 cohort were as follows: death due to all causes, 1.12 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.10\u20101.13) in men and 1.07 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.06\u20101.09) in women; lung cancer, 1.28 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.23\u20101.34) in men and 1.23 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.14\u20101.32) in women; and mesothelioma, 6.75 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 5.83\u20107.78) in men and 14.99 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 12.34\u201018.06) in women. These <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>s were significantly higher than expected. The increased <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content> of mesothelioma suggests the impact of occupational asbestos exposure among men and nonoccupational asbestos exposure among women in the long\u2010term residents\u2019 cohort. In addition, the high level of excess mortality from mesothelioma has persisted, despite the mixture of crocidolite and chrysotile no longer being used for three or four decades.<\/jats:p>","DOI":"10.1111\/cas.13930","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T04:03:11Z","timestamp":1547006591000},"page":"1076-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Population\u2010based cohort study on health effects of asbestos exposure in Japan"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-4199","authenticated-orcid":false,"given":"Ling","family":"Zha","sequence":"first","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences Department of Social and Environmental Medicine Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-3524","authenticated-orcid":false,"given":"Yuri","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences Department of Social and Environmental Medicine Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences Department of Social and Environmental Medicine Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences Department of Social and Environmental Medicine Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Public Health Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Kurumatani","sequence":"additional","affiliation":[{"name":"Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Studies Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Goji","sequence":"additional","affiliation":[{"name":"Amagasaki City Health and Welfare Bureau  Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-3483","authenticated-orcid":false,"given":"Tomotaka","family":"Sobue","sequence":"additional","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences Department of Social and Environmental Medicine Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Elimination of asbestos\u2010related diseases 2006.http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/69479\/?sequence=1. 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[in Japanese].Mainichi Newspaper.2005June 29;1."},{"key":"e_1_2_7_18_1","volume-title":"Demographic Data of Employees with Asbestos\u2010Related Diseases in Kanzaki Plant, A Now\u2010Defunct Asbestos Cement Plant in Amagasaki City","author":"Corporation K","year":"2005"},{"key":"e_1_2_7_19_1","volume-title":"A Report on the Amount of Asbestos Used in the Past by 136 Companies in Amagasaki City, Amagasaki, Hyogo Prefecture","author":"Amagasaki City","year":"2006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-063OC"},{"key":"e_1_2_7_21_1","unstructured":"Ministry of the Environment.Report of the survey on health impact of exposure to asbestos in Hyogo Prefecture [Government Publication]. [in Japanese]. Tokyo JP: Ministry of the Environment;2006.http:\/\/www.env.go.jp\/press\/files\/jp\/8031.pdf. Accessed September 21 2018."},{"key":"e_1_2_7_22_1","unstructured":"Ministry of the Environment.Report of the epidemiological study on exposure to asbestos in Amagasaki City [Government Publication]. [in Japanese]. Tokyo JP: Ministry of the Environment;2007.http:\/\/www.env.go.jp\/air\/asbestos\/commi_hefc\/rep_h18\/01.pdf. Accessed September 21 2018."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20743"},{"key":"e_1_2_7_24_1","first-page":"45","volume":"50","author":"Nakaya T","year":"2015","journal-title":"Geographical Reports of Tokyo Metropolitan University"},{"key":"e_1_2_7_25_1","unstructured":"Amagasaki City.The population of Amagasaki City [in Japanese].2002\u20102015.http:\/\/www.city.amagasaki.hyogo.jp\/shisei\/sogo_annai\/toukei\/012ama_jinko_0\/index.html. 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