{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:15:17Z","timestamp":1787166917591,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T00:00:00Z","timestamp":1552089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    Although a possible role of reproductive factors in lymphomagenesis has been hypothesized, results of epidemiological studies have been inconsistent. Here, we investigated the association between reproductive factors and the risk of lymphoid neoplasm and its subgroups. We used data from a large\u2010scale, population\u2010based prospective study in a Japanese cohort with 42\u00a0691 eligible women aged 40\u201069\u00a0years from 1990 to 1994. During a mean follow up of 18.7\u00a0years, we identified 176 cases of lymphoid neoplasm and 90 of non\u2010Hodgkin lymphoma (\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    ). A multivariable\u2010adjusted Cox proportional hazards regression model was used to estimate hazard ratios (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    ) and 95% confidence intervals (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) for the risk of lymphoid neoplasms and its subgroups according to self\u2010reported reproductive factors. Parous women had an increased risk of lymphoid neoplasm compared with nulliparous women (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a02.51, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    , 1.03\u20106.13). An increased risk of lymphoid neoplasms was found in women with later onset of menarche (\u226413\u00a0years old; reference: 14\u201015;\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a01.75, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    \u00a0=\u00a01.10\u20102.79: \u226516;\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a01.93, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    \u00a0=\u00a01.17\u20103.19:\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend: 0.01) and a shorter menstrual cycle (28\u201029\u00a0days; reference: \u226427;\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a01.60, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    \u00a0=\u00a01.05\u20102.43,\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend\u00a0=\u00a00.81). No association was observed between lymphoid neoplasms and other reproductive factors, including age at first birth, breastfeeding, type of menopause, or exogenous hormone use. Our study suggests that ever parity, late age at menarche and a short menstrual cycle length may be associated with the development of lymphoid neoplasms. The inconsistency seen in epidemiological research to date warrants further investigation.\n                  <\/jats:p>","DOI":"10.1111\/cas.13962","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T05:56:12Z","timestamp":1549346172000},"page":"1442-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Female reproductive factors and risk of lymphoid neoplasm: The Japan Public Health Center\u2010based Prospective Study"],"prefix":"10.1111","volume":"110","author":[{"given":"Shiori","family":"Tanaka","sequence":"first","affiliation":[{"name":"Epidemiology and Prevention Group Center for Public Health Sciences National Cancer Center  Tokyo Japan"},{"name":"Department of Global Health Policy Graduate School of Medicine The University of Tokyo  Tokyo 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