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The rat\u2010human chimeric antibody <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 has high affinity for human podoplanin and antibody\u2010dependent cellular cytotoxicity and is applicable for radioimmunotherapy (<jats:styled-content style=\"fixed-case\">RIT<\/jats:styled-content>) to enhance the antitumor effect. In the present study, we evaluated the in\u00a0vivo and in\u00a0vitro properties of radiolabeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 and the antitumor effect of <jats:styled-content style=\"fixed-case\">RIT<\/jats:styled-content> with <jats:sup>90<\/jats:sup>Y\u2010labeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 in an <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H226 (H226) malignant mesothelioma xenograft mouse model. <jats:sup>111<\/jats:sup>In\u2010labeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 bound specifically to H226 cells with high affinity, and accumulation was high in H226 tumors but low in major organs. <jats:styled-content style=\"fixed-case\">RIT<\/jats:styled-content> with <jats:sup>90<\/jats:sup>Y\u2010labeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 significantly suppressed tumor growth and prolonged survival without body weight loss and obvious adverse effects. Higher podoplanin expression levels were observed in human mesothelioma specimens, suggesting higher tumor accumulation of <jats:sup>90<\/jats:sup>Y\u2010labeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 in patients compared with the H226 tumor xenografts. Our findings suggest that <jats:sup>90<\/jats:sup>Y\u2010labeled <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>\u201012 is a promising <jats:styled-content style=\"fixed-case\">RIT<\/jats:styled-content> agent as a new therapeutic option for malignant mesothelioma that warrants further clinical studies to evaluate the dosimetry and efficacy in patients.<\/jats:p>","DOI":"10.1111\/cas.13979","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T02:25:31Z","timestamp":1551147931000},"page":"1653-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic efficacy evaluation of radioimmunotherapy with <sup>90<\/sup>Y\u2010labeled anti\u2010podoplanin antibody <scp>NZ<\/scp>\u201012 for mesothelioma"],"prefix":"10.1111","volume":"110","author":[{"given":"Hitomi","family":"Sudo","sequence":"first","affiliation":[{"name":"Department of Molecular Imaging and 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