{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:17Z","timestamp":1787013977513,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["221S0001"],"award-info":[{"award-number":["221S0001"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Primarily caused by exposure to asbestos, mesothelioma is a typical occupational disease. The latency of mesothelioma is as long as 20\u201040\u00a0years, and the cancer initially progresses mainly along the surfaces of pleura or peritoneum without forming masses. As symptoms do not develop until late stages, it has been challenging to diagnose this disease in its early stages and to carry out complete surgical removal. In responding to Japan's asbestos crisis in the mid\u20102000s, we have developed and improved ERC\/MSLN\u2010based serum and radiological markers and pioneered the use of an N\u2010ERC ELISA kit for screening populations at risk for asbestos exposure. In the present article, we review our research toward early diagnosis of asbestos\u2010related mesothelioma before symptoms develop and share our clinical experience of screening, diagnosing and monitoring of this disease. This paper is dedicated to the author (Dr Okio Hino) to commemorate the honor bestowed upon him as the recipient of the Mataro Nagayo Prize in 2018.<\/jats:p>","DOI":"10.1111\/cas.14001","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T22:00:35Z","timestamp":1553032835000},"page":"1518-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In commemoration of the 2018 Mataro Nagayo Prize: A road to early diagnosis and monitoring of asbestos\u2010related mesothelioma"],"prefix":"10.1111","volume":"110","author":[{"given":"Okio","family":"Hino","sequence":"first","affiliation":[{"name":"Department of Pathology and Oncology Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Department of Molecular Pathogenesis Graduate School of Medicine Juntendo University  Tokyo 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