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The circular <jats:styled-content style=\"fixed-case\">RNA <\/jats:styled-content><jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> is highly expressed in nasopharyngeal carcinoma according to our previous <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing data; however, the expression and functions of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> in cancers are still obscure. Therefore, in this study, we evaluated the expression of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> were detected by quantitative real\u2010time PCR, and the correlations of clinical features with <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> expression were analyzed by \u03c7<jats:sup>2<\/jats:sup> tests. Receiver operating characteristic curves were used to evaluate the clinical applications of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic>. The results showed that <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic>. Overall, our findings suggested that <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of <jats:italic>circ<jats:styled-content style=\"fixed-case\">MAN<\/jats:styled-content>1A2<\/jats:italic> in the pathogenesis of cancer.<\/jats:p>","DOI":"10.1111\/cas.14034","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T16:09:50Z","timestamp":1556813390000},"page":"2180-2188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["<i>circ<scp>MAN<\/scp>1A2<\/i> could serve as a novel serum biomarker for malignant tumors"],"prefix":"10.1111","volume":"110","author":[{"given":"Chun\u2010Mei","family":"Fan","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Carcinogenesis Xiangya Hospital Central South University Changsha China"},{"name":"The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute Central South University Changsha China"},{"name":"Hunan Key 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