{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:02Z","timestamp":1790630522709,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102013R1A1A2011536"],"award-info":[{"award-number":["NRF\u20102013R1A1A2011536"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016R1A5A2945889"],"award-info":[{"award-number":["NRF\u20102016R1A5A2945889"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well\u2010differentiated liposarcoma (<jats:styled-content style=\"fixed-case\">WDLPS<\/jats:styled-content>) and dedifferentiated liposarcoma (<jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content>) are the most common types of liposarcoma. Although <jats:styled-content style=\"fixed-case\">WDLPS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content> patients receive intensive treatment including radical surgery and systemic therapy, their overall 5\u2010year survival rates are 90% and 30%, respectively, indicating that <jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content> is clinically more aggressive. We examined whether adipogenic stimulation induces adipogenesis in human <jats:styled-content style=\"fixed-case\">WDLPS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content> cells by using dexamethasone, indomethacin, insulin, and 3\u2010isobutyl\u20101\u2010methylxanthine (<jats:styled-content style=\"fixed-case\">IBMX<\/jats:styled-content>), all putative medications or drugs. Functional in\u00a0vitro experiments showed that treatment with these four compounds induced adipogenic potency by transcriptional and translational upregulation of genes related to the maintenance of stemness and adipogenic differentiation. Using in\u00a0vivo xenograft models, we found that the induction of stemness and adipogenesis inhibited the tumorigenic potency of <jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content>. This study suggests a potential application of drug repositioning in which adipogenesis\u2010inducing compounds could be used to treat <jats:styled-content style=\"fixed-case\">DDLPS<\/jats:styled-content> patients in a clinical setting.<\/jats:p>","DOI":"10.1111\/cas.14036","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T06:41:37Z","timestamp":1557384097000},"page":"2676-2683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Adipogenesis induces growth inhibition of dedifferentiated liposarcoma"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-5263","authenticated-orcid":false,"given":"Yu Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Genomics and Molecular Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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