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As a secreted extracellular matrix protein, cysteine\u2010rich protein 61 (Cyr61) plays an important role in the resistance of solid tumors to chemotherapy, but its role in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> is unclear. In the present study, we observed that Cyr61 levels were upregulated in the plasma and bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) of patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> as well as in K562 cells. This upregulation of Cyr61 significantly decreased <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>\u2010induced cellular apoptosis of K562 cells through nuclear factor kappa B\/B\u2010cell lymphoma 2 pathways. Inhibition of Cyr61 restored the chemosensitivity of K562 cells to <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> both in\u00a0vitro and in\u00a0vivo. Thus, our results showed for the first time that Cyr61 plays an important role in regulating the chemosensitivity of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cells to <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>, suggesting that selectively targeting Cyr61 directly or its relevant effector pathways may provide potential value in improving the clinical response of patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1111\/cas.14083","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T13:03:53Z","timestamp":1559221433000},"page":"2421-2430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cysteine\u2010rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate 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