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However, other diverse information that is not easily readable using bioinformatics, including\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    modifications, has emerged as a novel diagnostic and innovative therapy owing to its multifunctional aspects. It is suggested that this breakthrough innovation might open new avenues for the elucidation of uncharacterized cancer cellular functions to develop more precise medical applications. The functional characteristics and regulatory mechanisms of\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    modifications, ie, the epitranscriptome (\n                    <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content>\n                    ), which reflects\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    metabolism, remains unclear, mainly due to detection methods being limited. Recent studies have revealed that N6\u2010methyl adenosine, the most common modification in\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    in eukaryotes, is affected in various types of cancer and, in some cases, cancer stem cells, but also affects cellular responses to viral infections. The\n                    <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content>\n                    can control cancer cell fate through\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    splicing, stability, nuclear export, and translation. Here we report on the recent progress of\n                    <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content>\n                    detection methods, and biological findings regarding the significance of\n                    <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content>\n                    in cancer precision medicine.\n                  <\/jats:p>","DOI":"10.1111\/cas.14095","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T02:03:45Z","timestamp":1560305025000},"page":"2318-2327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Significant epitranscriptomes in heterogeneous cancer"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-2315","authenticated-orcid":false,"given":"Masamitsu","family":"Konno","sequence":"first","affiliation":[{"name":"Department of Frontier Science for Cancer and 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