{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:41:39Z","timestamp":1767919299819,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown sex\u2010related differences in the incidence of adverse events following treatment with fluoropyrimidines, however the mechanism of this difference is unknown. We examined sex\u2010related differences in the safety of S\u20101 plus oxaliplatin (<jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>) and S\u20101 plus cisplatin (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) in 663 metastatic gastric cancer patients taking part in a phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> study. The incidences of leukopenia (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.9; <jats:italic>P\u00a0=\u00a0<\/jats:italic>.015), neutropenia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.2; <jats:italic>P\u00a0=\u00a0<\/jats:italic>.002), nausea (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.0; <jats:italic>P\u00a0=\u00a0<\/jats:italic>.009), and vomiting (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.8; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) were increased in women versus men treated with <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>, while vomiting (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.9; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and stomatitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.8; <jats:italic>P\u00a0=\u00a0<\/jats:italic>.043) were increased in women versus men treated with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>. In contrast, male patients treated with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> experienced thrombocytopenia more often (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.51; <jats:italic>P\u00a0=\u00a0<\/jats:italic>.009). The mean relative dose intensity of S\u20101 in <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content> was 75.4% in women and 81.4% in men (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.032). No difference in efficacy was observed between women and men undergoing either regimen. Sex\u2010related differences in adverse reactions during <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> treatment were confirmed in this phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> study. Further translational research studies are warranted to pursue the cause of this difference.<\/jats:p>","DOI":"10.1111\/cas.14117","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T14:49:32Z","timestamp":1561819772000},"page":"2875-2883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sex differences in the safety of S\u20101 plus oxaliplatin and S\u20101 plus cisplatin for patients with metastatic gastric cancer"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-8419","authenticated-orcid":false,"given":"Yasuhide","family":"Yamada","sequence":"first","affiliation":[{"name":"Gastrointestinal Medical Oncology Division National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasaburo","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University Hospital Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Osaka General Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Cancer Chemotherapy Center Osaka Medical College Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Fuse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka 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