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The present study was performed to investigate the carcinogenicity of\n                    <jats:styled-content style=\"fixed-case\">MWCNT<\/jats:styled-content>\n                    \u20107 when administered by the\n                    <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>\n                    method. Ten\u2010week\u2010old male F344\/Crj rats were divided into 3 groups and administered 0.5\u00a0\n                    <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                    vehicle, 0.250\u00a0\u03bcg\/\n                    <jats:styled-content style=\"fixed-case\">mL MWCNT<\/jats:styled-content>\n                    \u20107 or 0.250\u00a0\u03bcg\/\n                    <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                    crocidolite once a week for 12\u00a0weeks (total doses of 1.5\u00a0mg\/rat) and then observed for up to 104\u00a0weeks. Rats in the\n                    <jats:styled-content style=\"fixed-case\">MWCNT<\/jats:styled-content>\n                    \u20107 group began to die from pathologies associated with the development of malignant mesothelioma 35\u00a0weeks after the final\n                    <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>\n                    administration. Overall, the incidence of malignant mesothelioma in the\n                    <jats:styled-content style=\"fixed-case\">MWCNT<\/jats:styled-content>\n                    \u20107 group was significantly higher than in the vehicle or crocidolite groups.\n                  <\/jats:p>","DOI":"10.1111\/cas.14121","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T11:03:50Z","timestamp":1562065430000},"page":"2485-2492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["<scp>MWCNT<\/scp>\n                    \u20107 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats"],"prefix":"10.1111","volume":"110","author":[{"given":"Takamasa","family":"Numano","sequence":"first","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-3639","authenticated-orcid":false,"given":"David B.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelgied","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"},{"name":"Department of Experimental Pathology and Tumor Biology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"},{"name":"Department of Forensic Medicine and Toxicology Faculty of Veterinary Medicine Beni Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"El\u2010Gazzar","sequence":"additional","affiliation":[{"name":"Nanotoxicology Project Nagoya City University Nagoya Japan"},{"name":"Department of Experimental Pathology and Tumor Biology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"},{"name":"Department of Forensic Medicine and Toxicology Faculty of Veterinary Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-6708","authenticated-orcid":false,"given":"Dina","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Clinical Toxicology Faculty of Medicine Assiut University Assiut 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