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To solve this issue, we developed FF\u201010832 as liposome\u2010encapsulated gemcitabine to maintain a high concentration of gemcitabine in peritoneal tumors from the circulation and ascites. A syngeneic mouse model of peritoneal dissemination using murine Colon26 cell line was selected to compare the drug efficacy and pharmacokinetics of FF\u201010832 with those of gemcitabine. Despite the single intravenous administration, FF\u201010832 treatment enabled long\u2010term survival of the lethal model mice as compared with those treated with gemcitabine. Pharmacokinetic analysis clarified that FF\u201010832 could achieve a more effective gemcitabine delivery to peritoneal tumors owing to better stability in the circulation and ascites. The novel liposome\u2010encapsulated gemcitabine FF\u201010832 may be a curative therapeutic tool for cancer patients with unresectable peritoneal dissemination via the effective delivery of gemcitabine to target tumors.<\/jats:p>","DOI":"10.1111\/cas.14123","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T15:23:50Z","timestamp":1562426630000},"page":"2933-2940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["FF\u201010832 enables long survival via effective gemcitabine accumulation in a lethal murine peritoneal dissemination model"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-3666","authenticated-orcid":false,"given":"Tamami","family":"Higuchi","sequence":"first","affiliation":[{"name":"Department of Oncology Clinical Development Gunma University, Graduate School of Medicine Maebashi Japan"},{"name":"Pharmaceutical and Healthcare 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