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Maintenance of skeletal muscle is an essential concern in cancer treatment. In nutritional intervention, it is important to focus on differences in metabolism between tumor and skeletal muscle. We examined the influence of oral intake of glucose (0%, 10%, 50%) and 2% medium\u2010chain fatty acid (lauric acid, <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content>, C12:0) on tumor growth and skeletal muscle atrophy in mouse peritoneal metastasis models using <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>26 mouse colon cancer cells and <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>29 human colon cancer cells. After 2\u00a0weeks of experimental breeding, skeletal muscle and tumor were removed and analyzed. Glucose intake contributed to prevention of skeletal muscle atrophy in a sugar concentration\u2010dependent way and also promoted tumor growth. <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> ingestion elevated the level of skeletal muscle protein and suppressed tumor growth by inducing tumor\u2010selective oxidative stress production. When a combination of glucose and <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> was ingested, skeletal muscle mass increased and tumor growth was suppressed. Our results confirmed that although glucose is an important nutrient for the prevention of skeletal muscle atrophy, it may also foster tumor growth. However, the ingestion of <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> inhibited tumor growth, and its combination with glucose promoted skeletal muscle integrity and function, without stimulating tumor growth. These findings suggest novel strategies for the prevention of skeletal muscle atrophy.<\/jats:p>","DOI":"10.1111\/cas.14170","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T06:48:26Z","timestamp":1566370106000},"page":"3391-3399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Giving combined medium\u2010chain fatty acids and glucose protects against cancer\u2010associated skeletal muscle atrophy"],"prefix":"10.1111","volume":"110","author":[{"given":"Takuya","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Nara Medical University Nara Japan"},{"name":"Division of Rehabilitation Hanna Central Hospital Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Nara Medical University Nara 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