{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:55Z","timestamp":1792118755002,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the proteasome inhibitor bortezomib (<jats:styled-content style=\"fixed-case\">BTZ<\/jats:styled-content>) shows excellent efficacy in multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>), a fraction of patients has a suboptimal or no response to this agent. In addition, <jats:styled-content style=\"fixed-case\">BTZ<\/jats:styled-content>\u2010induced peripheral neuropathy (Bi<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>), a frequent side\u2010effect of this therapy, limits its use in some patients. This study aimed to explore serum lipid biomarker candidates to predict the response to <jats:styled-content style=\"fixed-case\">BTZ<\/jats:styled-content> and the severity of Bi<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>. Fifty\u2010nine serum samples were collected from patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> prior to receiving <jats:styled-content style=\"fixed-case\">BTZ<\/jats:styled-content> plus low\u2010dose dexamethasone therapy. Serum levels of phospholipids, sphingolipids, neutral lipids, and polyunsaturated fatty acids and their oxidation products were measured by a comprehensive lipidomic study. Overall, 385 lipid metabolites were identified in patients\u2019 sera; lower levels of several glycerophospholipids, sphingolipids, and cholesteryl esters were associated with a poor treatment response. Metabolites related to platelet\u2010activating factor biosynthesis and cholesterol metabolism appeared particularly relevant. Furthermore, several lysophosphatidylcholines, phosphatidylcholines, ceramides, neutral lipids, and oxidative fatty acids were significantly increased or decreased in patients with Bi<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> grades ranging from G0 to G3. Among these compounds, mediators reportedly inducing myelin breakdown and stimulating inflammatory responses were prominent. Although further study is necessary to validate these biomarker candidates, our results contribute to the development of predictive biomarkers for response to <jats:styled-content style=\"fixed-case\">BTZ<\/jats:styled-content> treatment, or ensuing severe Bi<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>, in patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.14178","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T04:33:06Z","timestamp":1566621186000},"page":"3267-3274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-4137","authenticated-orcid":false,"given":"Keiko","family":"Maekawa","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmaceutical Sciences Doshisha Women's College of Liberal Arts Kyoto Japan"},{"name":"Division of Medical Safety Science National Institute of Health Sciences Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9617-486X","authenticated-orcid":false,"given":"Masaki","family":"Ri","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"},{"name":"Division of Blood Transfusion Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Faculty of Pharmaceutical Sciences Kanazawa University Kanazawa Japan"},{"name":"WPI Nano Life Science Institute Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sekine","sequence":"additional","affiliation":[{"name":"Center for Preventive Medical Science Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Tumor Immunology Aichi Medical University School of Medicine Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tohkin","sequence":"additional","affiliation":[{"name":"Department of Regulatory Science Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Miyata","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Science Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Medical Safety Science National Institute of Health Sciences Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-960X","authenticated-orcid":false,"given":"Shinsuke","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70187-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70081-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12172"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00638.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801479"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-3163"},{"key":"e_1_2_7_8_1","first-page":"392","article-title":"Comparative proteomic profiling of sera from patients with refractory multiple myeloma reveals potential biomarkers predicting response to bortezomib\u2010based therapy","volume":"127","author":"\u0141uczak M","year":"2017","journal-title":"Pol Arch Intern Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-017-0169-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.02.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28932"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091806"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-017-0189-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38980"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00295-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0375-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61011-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.07.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360491"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.03.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00402.2006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01040"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.04.014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M006007"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.14178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.14178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.14178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:25:26Z","timestamp":1722353126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.14178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/cas.14178"],"URL":"https:\/\/doi.org\/10.1111\/cas.14178","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,19]]},"assertion":[{"value":"2019-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}