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We undertook a systematic review to investigate the prognostic significance of blood microvessel density (<jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>) and lymphatic vessel density (<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients. We carried out a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content> markers in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> were systematically retrieved. Our results showed that <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content> markers, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105, factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>, lymphatic vessel endothelial hyaluronan receptor\u20101, and D2\u201040 were evaluated in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>. Two out of three studies suggested that a high number of D2\u201040<jats:sup>+<\/jats:sup> vessels predicated low overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>); the third study reported that the ratio of D2\u201040<jats:sup>+<\/jats:sup> over factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content><jats:sup>+<\/jats:sup> vessels is associated with low <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Most of the other markers had controversial results for prognostication. We found higher expression of <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LVD<\/jats:styled-content> markers were commonly, but not always, associated with shorter survival in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2\u201040) with larger patient cohorts are needed.<\/jats:p>","DOI":"10.1111\/cas.14189","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T07:48:10Z","timestamp":1567928890000},"page":"3424-3433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review"],"prefix":"10.1111","volume":"110","author":[{"given":"Rabeia","family":"Almahmoudi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Clinicum University of Helsinki Helsinki Finland"},{"name":"Translational Immunology Research Program (TRIMM) University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merimaija","family":"Kasanen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Clinicum 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