{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:43:51Z","timestamp":1792183431058,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk010839"],"award-info":[{"award-number":["JP19fk010839"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29\u2010ganseisaku\u2010shitei\u2010001"],"award-info":[{"award-number":["H29\u2010ganseisaku\u2010shitei\u2010001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently took advantage of the universal expression of cell adhesion molecule 1 (CADM1) by CD4<jats:sup>+<\/jats:sup> cells infected with HTLV\u20101 and the downregulation of CD7 expression that corresponds with the oncogenic stage of HTLV\u20101\u2010infected cells to develop a flow cytometric system using CADM1 versus CD7 plotting of CD4<jats:sup>+<\/jats:sup> cells. We risk\u2010stratified HTLV\u20101 asymptomatic carriers (AC) and indolent adult T\u2010cell leukemia\/lymphoma (ATL) cases based on the CADM1<jats:sup>+<\/jats:sup> percentage, in which HTLV\u20101\u2010infected clones are efficiently enriched. AC and indolent ATL cases were initially classified according to their CADM1<jats:sup>+<\/jats:sup> cell percentage. Follow\u2010up clinical and flow cytometric data were obtained for 71 cases. In G1 (CADM1<jats:sup>+<\/jats:sup> \u2264 10%) and G2 (10% &lt; CADM1<jats:sup>+<\/jats:sup> \u2264 25%) cases, no apparent clinical disease progression was observed. In G3 (25% &lt; CADM1<jats:sup>+<\/jats:sup> \u2264 50%) cases, five out of nine (55.5%) cases progressed from AC to smoldering\u2010type ATL. In G4 (50% &lt; CADM1<jats:sup>+<\/jats:sup>) cases, the cumulative incidence of receiving systemic chemotherapy at 3\u00a0years was 28.4%. Our results indicate that the percentage of the CD4<jats:sup>+<\/jats:sup>CADM1<jats:sup>+<\/jats:sup> population predicts clinical disease progression: G1 and G2 cases, including AC cases, are stable and considered to be at low risk; G3 cases, including advanced AC cases and smoldering\u2010type ATL cases based on the Shimoyama criteria, are considered to have intermediate risk; and G4 cases, which are mainly indolent ATL cases, are unstable and at high risk of acute transformation.<\/jats:p>","DOI":"10.1111\/cas.14219","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T18:35:21Z","timestamp":1571855721000},"page":"3746-3753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["CD4<sup>+<\/sup>CADM1<sup>+<\/sup> cell percentage predicts disease progression in HTLV\u20101 carriers and indolent adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0883-2920","authenticated-orcid":false,"given":"Junya","family":"Makiyama","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Research Hospital, The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Molecular Therapy Advanced Clinical Research Center The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Watanabe","sequence":"additional","affiliation":[{"name":"IMSUT Clinical Flow Cytometry Laboratory The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Research Hospital The Institute of Medical Science The University of Tokyo Tokyo Japan"},{"name":"Division of Stem Cell Therapy The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyotaka","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Research Hospital, The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arinobu","family":"Tojo","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Research Hospital, The Institute of Medical Science The University of Tokyo Tokyo Japan"},{"name":"Division of Molecular Therapy Advanced Clinical Research Center The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Research Hospital, The Institute of Medical Science The University of Tokyo Tokyo Japan"},{"name":"Future Center Initiative The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Uchimaru","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Research Hospital, The Institute of Medical Science The University of Tokyo Tokyo Japan"},{"name":"Laboratory of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo 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