{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:30:49Z","timestamp":1774326649887,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The revised WHO classification newly defined the entities \u201cHigh\u2010grade B\u2010cell lymphoma with <jats:italic>MYC<\/jats:italic> and <jats:italic>BCL2<\/jats:italic>, and\/or <jats:italic>BCL6<\/jats:italic> rearrangements (HGBL\u2010DH\/TH)\u201d and \u201cHGBL, NOS.\u201d Standard immunochemotherapy for diffuse large B\u2010cell lymphoma (DLBCL), R\u2010CHOP, is insufficient for HGBL patients, and there are currently no optimized therapeutic regimens for HGBL. We previously reported that <jats:italic>CCND3<\/jats:italic>, which encodes cyclin D3, harbored high mutation rates in Burkitt lymphoma (BL), HGBL and a subset of DLBCL. Furthermore, the knockdown of cyclin D3 expression was toxic to germinal center (GC)\u2010derived B\u2010cell lymphomas. Thus, the fundamental function of cyclin D3 is important for the pathogenesis of GC\u2010derived B\u2010cell lymphoma. We herein used two structurally different CDK4\/6 inhibitors, palbociclib and abemaciclib, and examined their suppressive effects on cell proliferation and their ability to induce apoptosis in various aggressive B\u2010cell lymphoma cell lines. The results obtained demonstrated that abemaciclib more strongly suppressed cell proliferation and induced apoptosis in GC\u2010derived B\u2010cell lymphoma cell lines than the control, but only slightly inhibited those features in activated B\u2010cell (ABC)\u2010like DLBCL cell lines. Palbociclib exerted partial or incomplete effects compared with the control and the effect was intermediate between abemaciclib and the control. Moreover, the effects of abemaciclib appeared to depend on cyclin D3 expression levels based on the results of the expression analysis of primary aggressive B\u2010cell lymphoma samples. Therefore, abemaciclib has potential as a therapeutic agent for aggressive GC\u2010derived B\u2010cell lymphomas.<\/jats:p>","DOI":"10.1111\/cas.14286","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T02:23:56Z","timestamp":1576635836000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Abemaciclib, a CDK4\/6 inhibitor, exerts preclinical activity against aggressive germinal center\u2010derived B\u2010cell lymphomas"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-9839","authenticated-orcid":false,"given":"Yuka","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Hematology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-1409","authenticated-orcid":false,"given":"Shuji","family":"Momose","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University Kawagoe Japan"},{"name":"Institute of Pathology Comprehensive Cancer Center Mainfranken University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Tabayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morihiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morihiko","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-5331","authenticated-orcid":false,"given":"Michihide","family":"Tokuhira","sequence":"additional","affiliation":[{"name":"Department of Hematology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology Comprehensive Cancer Center Mainfranken University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kizaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Tamaru","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. 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