{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:58:34Z","timestamp":1790521114602,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The interaction between CD47 and signal\u2010regulatory protein\u2010\u03b1 (SIRP\u03b1) inhibits phagocytosis, thus affecting the clinical outcomes of neoplastic diseases. Although CD47 upregulation is associated with poor prognosis in several malignancies, the effect of SIRP\u03b1 expression and its coexpression with CD47 remains unclear. This study aimed to investigate the clinicopathologic effect of CD47 and SIRP\u03b1 expression in diffuse large B\u2010cell lymphoma (DLBCL). Immunostaining of 120 biopsy samples showed that CD47 is primarily expressed in tumor cells, whereas SIRP\u03b1 is expressed in nonneoplastic stromal cells, mostly macrophages. CD47<jats:sup>high<\/jats:sup> cases showed higher MYC protein expression and lower <jats:italic>MYC<\/jats:italic> translocation. The SIRP\u03b1<jats:sup>high<\/jats:sup> cases presented significantly shorter overall survival (OS) and progression\u2010free survival (PFS) than SIRP\u03b1<jats:sup>low<\/jats:sup> cases in the activated B\u2010cell (ABC) subtype of DLBCL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02, respectively). Both CD47<jats:sup>high<\/jats:sup> and SIRP\u03b1<jats:sup>high<\/jats:sup> presented significantly shorter OS and PFS than other cases among all DLBCL patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004, respectively), and the ABC type (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008, respectively) but not the germinal center B\u2010cell type. Both CD47<jats:sup>high<\/jats:sup> and SIRP\u03b1<jats:sup>high<\/jats:sup> yielded a constant independent prognostic value for OS and PFS in multivariate analysis (hazard ratio [HR], 2.93; 95% confidence interval [CI], 1.20\u20107.43; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02; and HR, 2.87; 95% CI, 1.42\u20105.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003, respectively). To the best of our knowledge, this is the first study to report that combinatorial CD47 and SIRP\u03b1 expression is a potential independent prognostic factor for DLBCL. Evaluation of CD47 and SIRP\u03b1 expression could be useful before CD47 blockade therapy.<\/jats:p>","DOI":"10.1111\/cas.14437","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T07:04:46Z","timestamp":1588057486000},"page":"2608-2619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Combination of CD47 and signal\u2010regulatory protein\u2010\u03b1 constituting the \u201cdon\u2019t eat me signal\u201d is a prognostic factor in diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2207-4508","authenticated-orcid":false,"given":"Ryo","family":"Kazama","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"},{"name":"Department of Internal Medicine Sakai City Medical Center Sakai 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"},{"name":"Department of Clinical Studies Radiation Effects Research Foundation Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Niigata University Faculty of Medicine Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume 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