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Plastin 1 (PLS1) is an actin\u2010bundling protein that has been implicated in the structure of intestinal epithelial microvilli; however, its role in CRC metastasis has not yet been determined. In this study, we demonstrated that PLS1 is highly expressed in 33.3% (45\/135) of CRC patients and is correlated with lymph node metastasis and poor survival. In in vitro and in vivo experiments, PLS1 induced the migration and invasion of CRC cells and the metastases to the liver and lung in mice. Moreover, the expressions of key factors for CRC metastases, matrix metalloproteinase (MMP) 9 and 2, were enhanced by PLS1, which was dependent on phosphorylating ERK1\/2 activated by IQGAP1\/Rac1 signaling. The connection between these signals and PLS1 was further confirmed in CRC tissues of patients and the metastatic nodules from a mouse model. These findings suggest that PLS1 promotes CRC metastasis through the IQGAP1\/Rac1\/ERK pathway. Targeting PLS1 may provide a potential approach to inhibit the metastasis of CRC cells.<\/jats:p>","DOI":"10.1111\/cas.14438","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T02:56:41Z","timestamp":1588215401000},"page":"2861-2871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Plastin 1 drives metastasis of colorectal cancer through the IQGAP1\/Rac1\/ERK pathway"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-5776","authenticated-orcid":false,"given":"Tongtong","family":"Zhang","sequence":"first","affiliation":[{"name":"Medical Research Center The Third People\u2019s Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu 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