{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:23:46Z","timestamp":1752229426838,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570197","81670150"],"award-info":[{"award-number":["81570197","81670150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rapid spread of coronavirus disease 2019 (COVID\u201019) represented the most serious issue to public health globally. Hematological patients as immunocompromised hosts are vulnerable to severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) infection. There is little information available regarding the clinical features of hematological patients concomitant with COVID\u201019. In this study, 9 concomitant patients were analyzed for their clinical manifestations, laboratory data, radiological findings, and immunologic features. The median age was 50\u00a0years (range, 17\u201068\u00a0years) and 6 patients were male. Seven patients were infected through hospital\u2010associated transmission and other 2 through community\u2010associated transmission. Onset of COVID\u201019 in all patients occurred during routine treatments for their hematological diseases. Eight patients were classified as moderate and 1 patient as critically ill COVID\u201019. Four patients died, 1 from leukemia progression, 2 from life\u2010threatening secondary infection, and the other from respiratory failure caused by COVID\u201019. Abruptly elevated levels of cytokines were often correlated with progressive hematological disease or concurrent\u00a0bacterial\u00a0infections. Two patients had atypical computed tomography (CT) imaging findings of COVID\u201019. The median interval from the first CT scan imaging to improvement in survivors was 40\u00a0days (range, 14\u201051\u00a0days). Four of 5 survivors had negative serological tests 1\u00a0month after symptom onset. Positive viral load in 4 survivors lasted longer than 45\u00a0days. Our results indicated concomitant patients formed a distinct subgroup characterized by atypical clinical features, defective viral clearance, and lower level of SARS\u2010CoV\u20102\u2010specific Abs. Targeted therapies that impair host humoral immunity should be avoided. These findings will be helpful to tailor appropriate management for the concomitant patients.<\/jats:p>","DOI":"10.1111\/cas.14544","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T15:33:38Z","timestamp":1593790418000},"page":"3379-3385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical characteristics of hematological patients concomitant with COVID\u201019"],"prefix":"10.1111","volume":"111","author":[{"given":"Xiaoxi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaoxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fankai","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0152-639X","authenticated-orcid":false,"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-9230","authenticated-orcid":false,"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) outbreak.https:\/\/www.who.int. Accessed January 30 2020."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_8_4_1","first-page":"m1036","article-title":"Covid\u201019: WHO declares pandemic because of \u201calarming levels\u201d of spread, severity, and inaction","volume":"368","author":"Mahase E","year":"2020","journal-title":"RMD Open"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30074-0"},{"key":"e_1_2_8_9_1","unstructured":"Guidance for Corona Virus Disease 2019: Prevention Control Diagnosis and management.http:\/\/covid19.21wecan.com\/covid19en\/c100021\/common_list.shtml. 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